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Clopidogrel (Plavix)

Clopidogrel (Plavix) SUMMARY: Clopidogrel is an inhibitor of platelet aggregation, indicated for the prevention of ischemic stroke and in-stent thrombosis. However, it has a number of drawbacks, including an increased risk of hemorrhage; a clinical effect that is slow in onset and irreversible; a genetically determined variability in its clinical potency; and interactions with other commonly administered drugs. ABBREVIATIONS Act-Met active metabolite of clopidogrel ADP adenosine diphosphate AHA American Hospital Association GI gastrointestinal GPIIb/IIIa glycoprotein IIb/IIIa PPI proton pump inhibitor VWF von Willebrand factor http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2011 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A2913
pmid
22135129
Publisher site
See Article on Publisher Site

Abstract

SUMMARY: Clopidogrel is an inhibitor of platelet aggregation, indicated for the prevention of ischemic stroke and in-stent thrombosis. However, it has a number of drawbacks, including an increased risk of hemorrhage; a clinical effect that is slow in onset and irreversible; a genetically determined variability in its clinical potency; and interactions with other commonly administered drugs. ABBREVIATIONS Act-Met active metabolite of clopidogrel ADP adenosine diphosphate AHA American Hospital Association GI gastrointestinal GPIIb/IIIa glycoprotein IIb/IIIa PPI proton pump inhibitor VWF von Willebrand factor

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Dec 1, 2011

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