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Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy

Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy ORIGINAL RESEARCH ADULT BRAIN Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy O. Rapalino, A. Pourvaziri, M. Maher, A. Jaramillo-Cardoso, B.L. Edlow, J. Conklin, S. Huang, B. Westover, J.M. Romero, E. Halpern, R. Gupta, S. Pomerantz, P. Schaefer, R.G. Gonzalez, S.S. Mukerji, and M.H. Lev ABSTRACT BACKGROUND AND PURPOSE: Patients infected with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) can de- velop a spectrum of neurological disorders, including a leukoencephalopathy of variable severity. Our aim was to characterize imaging, lab, and clinical correlates of severe coronavirus disease 2019 (COVID-19) leukoencephalopathy, which may provide insight into the SARS-CoV-2 pathophysiology. MATERIALS AND METHODS: Twenty-seven consecutive patients positive for SARS-CoV-2 who had brain MR imaging following in- tensive care unit admission were included. Seven (7/27, 26%) developed an unusual pattern of “leukoencephalopathy with reduced diffusivity” on diffusion-weighted MR imaging. The remaining patients did not exhibit this pattern. Clinical and laboratory indices, as well as neuroimaging findings, were compared between groups. RESULTS: The reduced-diffusivity group had a significantly higher body mass index (36 versus 28 kg/m , P , .01). Patients with reduced diffusivity trended toward more frequent acute renal failure (7/7, 100% versus 9/20, 45%; P ¼ .06) and lower http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy

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Publisher
American Journal of Neuroradiology
Copyright
© 2021 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6966
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL RESEARCH ADULT BRAIN Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy O. Rapalino, A. Pourvaziri, M. Maher, A. Jaramillo-Cardoso, B.L. Edlow, J. Conklin, S. Huang, B. Westover, J.M. Romero, E. Halpern, R. Gupta, S. Pomerantz, P. Schaefer, R.G. Gonzalez, S.S. Mukerji, and M.H. Lev ABSTRACT BACKGROUND AND PURPOSE: Patients infected with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) can de- velop a spectrum of neurological disorders, including a leukoencephalopathy of variable severity. Our aim was to characterize imaging, lab, and clinical correlates of severe coronavirus disease 2019 (COVID-19) leukoencephalopathy, which may provide insight into the SARS-CoV-2 pathophysiology. MATERIALS AND METHODS: Twenty-seven consecutive patients positive for SARS-CoV-2 who had brain MR imaging following in- tensive care unit admission were included. Seven (7/27, 26%) developed an unusual pattern of “leukoencephalopathy with reduced diffusivity” on diffusion-weighted MR imaging. The remaining patients did not exhibit this pattern. Clinical and laboratory indices, as well as neuroimaging findings, were compared between groups. RESULTS: The reduced-diffusivity group had a significantly higher body mass index (36 versus 28 kg/m , P , .01). Patients with reduced diffusivity trended toward more frequent acute renal failure (7/7, 100% versus 9/20, 45%; P ¼ .06) and lower

Journal

American Journal of Neuroradiology – American Journal of Neuroradiology

Published: Apr 1, 2021

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