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ORIGINAL RESEARCH ADULT BRAIN Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio X A. Hagiwara, X M. Hori, X K. Yokoyama, X M. Nakazawa, X R. Ueda, X M. Horita, X C. Andica, X O. Abe, and X S. Aoki ABSTRACT BACKGROUNDANDPURPOSE: Myelin and axon volume fractions can now be estimated via MR imaging in vivo, as can the g-ratio, which equals the ratio of the inner to the outer diameter of a nerve fiber. The purpose of this study was to evaluate WM damage in patients with MS via this novel MR imaging technique. MATERIALS AND METHODS: Twenty patients with relapsing-remitting MS with a combined total of 149 chronic plaques were analyzed. Myelin volume fraction was calculated based on simultaneous tissue relaxometry. Intracellular and CSF compartment volume fractions were quantified via neurite orientation dispersion and density imaging. Axon volume fraction and g-ratio were calculated by combining thesemeasurements.Myelinandaxonvolumefractionsandg-ratioweremeasuredinplaques,periplaqueWM,andnormal-appearingWM. RESULTS: All metrics differed significantly across the 3 groups (P .001, except P .027 for g-ratio between periplaque WM and normal-appearing WM). Those in plaques differed most from those in normal-appearing WM. The percentage
American Journal of Neuroradiology – American Journal of Neuroradiology
Published: Oct 1, 2017
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