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Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis

Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis REVIEW ARTICLE Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis D.A. Lakhani, K.G. Schilling, J. Xu, and F. Bagnato ABSTRACT SUMMARY: Conventional MR imaging techniques are sensitive to pathologic changes of the brain and spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity. By isolating the signal contribution from different tissue compart- ments, newly developed advanced multicompartment diffusion MR imaging models have the potential to detect specific tissue subtypes and associated injuries with increased pathologic specificity. These models include neurite orientation dispersion and den- sity imaging, diffusion basis spectrum imaging, multicompartment microscopic diffusion MR imaging with the spherical mean tech- nique, and models enabled through high-gradient diffusion MR imaging. In this review, we provide an appraisal of the current literature on the physics principles, histopathologic validation, and clinical applications of each of these techniques in both brains and spinal cords of patients with MS. We discuss limitations of each of the methods and directions that future research could take to provide additional validation of their roles as biomarkers of axonal and myelin injury in MS. ABBREVIATIONS: AD ¼ axial diffusivity; D ¼ intra-axonal diffusivity; DBSI ¼ diffusion basis spectrum imaging; http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis

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Publisher
American Journal of Neuroradiology
Copyright
© 2020 by American Journal of Neuroradiology
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A6484
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis D.A. Lakhani, K.G. Schilling, J. Xu, and F. Bagnato ABSTRACT SUMMARY: Conventional MR imaging techniques are sensitive to pathologic changes of the brain and spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity. By isolating the signal contribution from different tissue compart- ments, newly developed advanced multicompartment diffusion MR imaging models have the potential to detect specific tissue subtypes and associated injuries with increased pathologic specificity. These models include neurite orientation dispersion and den- sity imaging, diffusion basis spectrum imaging, multicompartment microscopic diffusion MR imaging with the spherical mean tech- nique, and models enabled through high-gradient diffusion MR imaging. In this review, we provide an appraisal of the current literature on the physics principles, histopathologic validation, and clinical applications of each of these techniques in both brains and spinal cords of patients with MS. We discuss limitations of each of the methods and directions that future research could take to provide additional validation of their roles as biomarkers of axonal and myelin injury in MS. ABBREVIATIONS: AD ¼ axial diffusivity; D ¼ intra-axonal diffusivity; DBSI ¼ diffusion basis spectrum imaging;

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: May 1, 2020

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