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A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth

A New Ultrasound Marker for Bedside Monitoring of Preterm Brain Growth BACKGROUND AND PURPOSE: Preterm neonates are at risk for neurodevelopmental impairment, but reliable, bedside-available markers to monitor preterm brain growth during hospital stay are still lacking. The aim of this study was to assess the feasibility of corpus callosum–fastigium length as a new cranial sonography marker for monitoring of preterm brain growth. MATERIALS AND METHODS: In this longitudinal prospective cohort study, cranial ultrasound was planned on the day of birth, days 1, 2, 3, and 7 of life; and then weekly until discharge in preterm infants born before 29 weeks of gestational age. Reproducibility and associations between clinical variables and corpus callosum–fastigium growth trajectories were studied. RESULTS: A series of 1–8 cranial ultrasounds was performed in 140 infants (median gestational age at birth, 27 +2 weeks (interquartile range, 26 +1 to 28 +1 ; 57.9% male infants). Corpus callosum–fastigium measurements showed good-to-excellent agreement for inter- and intraobserver reproducibility (intraclass correlation coefficient >0.89). Growth charts for preterm infants between 24 and 32 weeks of gestation were developed. Male sex and birth weight SD score were positively associated with corpus callosum–fastigium growth rate. CONCLUSIONS: Corpus callosum–fastigium length measurement is a new reproducible marker applicable for bedside monitoring of preterm brain growth during neonatal intensive care stay. ABBREVIATIONS: BW birth weight CC corpus callosum CCF corpus callosum–fastigium CUS cranial ultrasound GA gestational age HELLP hemolysis, elevated liver enzymes, low platelet count NICU neonatal intensive care unit http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

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Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2016 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A4731
pmid
26988817
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND AND PURPOSE: Preterm neonates are at risk for neurodevelopmental impairment, but reliable, bedside-available markers to monitor preterm brain growth during hospital stay are still lacking. The aim of this study was to assess the feasibility of corpus callosum–fastigium length as a new cranial sonography marker for monitoring of preterm brain growth. MATERIALS AND METHODS: In this longitudinal prospective cohort study, cranial ultrasound was planned on the day of birth, days 1, 2, 3, and 7 of life; and then weekly until discharge in preterm infants born before 29 weeks of gestational age. Reproducibility and associations between clinical variables and corpus callosum–fastigium growth trajectories were studied. RESULTS: A series of 1–8 cranial ultrasounds was performed in 140 infants (median gestational age at birth, 27 +2 weeks (interquartile range, 26 +1 to 28 +1 ; 57.9% male infants). Corpus callosum–fastigium measurements showed good-to-excellent agreement for inter- and intraobserver reproducibility (intraclass correlation coefficient >0.89). Growth charts for preterm infants between 24 and 32 weeks of gestation were developed. Male sex and birth weight SD score were positively associated with corpus callosum–fastigium growth rate. CONCLUSIONS: Corpus callosum–fastigium length measurement is a new reproducible marker applicable for bedside monitoring of preterm brain growth during neonatal intensive care stay. ABBREVIATIONS: BW birth weight CC corpus callosum CCF corpus callosum–fastigium CUS cranial ultrasound GA gestational age HELLP hemolysis, elevated liver enzymes, low platelet count NICU neonatal intensive care unit

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Aug 1, 2016

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