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Google Scholar CrossRef Search ADS 24 Nomaguchi T, Kimura Y, Takai Y. Estimation of minimum electron dose necessary to resolve molecular structure of deoxyribonucleic acid by phase transmission ...
Abstract Cryogenic electron microscopy can be widely applied to biological specimens from the molecular to the cellular scale. In single-particle analysis, 3D structures may be obtained in high ...
to the minimum of 4.2 keV to achieve a concentrated beam of low energy spread [24]. The strength of the first condenser lens (C1) was adjusted to achieve the desired dose rate of 0.93 electrons per pixel per ...
) estimates with SAXS carry an error of about 10% [38]. However, here the predicted molecular weight of the dimer (48.7 kDa) is ~20% lower than the actual MW (60 kDa), while the calculated scattering ...
a higher resolution by increasing the magnification of the microscope, it is important to keep the electron dose per nm2 to a minimum to prevent mass loss of the protein [5], and thus, an incorrect mass ...
and membrane fusion. Averaging up to tens of thousands of particle images by single-particle cryoEM method has resolved in situ structures of capsid proteins [7–9] and the capsid-associated tegument protein ...
microscopy CL condenser lens CTF contrast transfer function DLR dose -limited resolution EH electron holography HFPP hole-free phase plate MIP mean inner potential, V0 MTC mass thickness contrast OA objective ...
knowledge and molecular understanding of silver stress can be translated into new antibacterial approaches in clinic. Our study resolves long-standing questions on how Ag+ exerts its antimicrobial activity ...
package insert emphasizes using the minimum necessary ESA dose [4]. Several studies have shown that supplementing ESA with aggressive intravenous (IV) iron treatment improves Hb compared with using ESA ...
, and morphology. For nanoparticles, electron microscopy is normally required to capture images with the necessary resolution, and it is the only technique that provides reliable information regarding shape ...
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