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control of the concentration gradient for diffusion -based as well as flow-based gradient generation.28,55,56 In this type of microfluidic device , cells can be exposed to gradients of dynamically switching ...
surfaces. J Micromech Microeng 2001 ; 11 : 532 -541. 19 Thiebaud P, Lauer L, Knoll W, Offenhausser A. PDMS device for patterned application of microfluids to neuronal cells arranged by microcontact printing ...
endothelial cells (ECs), within 3D fibrin gels in microfluidic devices . We demonstrated that the effect of these molecules is dependent on direct heterotypic cell – cell contact. Moreover, we found a significant ...
influence proliferation and differentiation of neural progenitor cells . Earlier, human NSCs were cultured in a microfluidic device with a growth factor gradient [14]. A microfluidic device in which postnatal ...
. Complete lysis is evident as the pressure approaches 30 kPa. Kim et al.21 use a strictly mechanical method for lysing cells in a spinning microfluidic CD device . The driving mechanical principle to break up ...
reproducibility which are not well suited for studying slow-growing mammalian cells . Although microfluidic device design have allowed for generating stable, complex gradients of diffusible molecules, the flow ...
describes the directed migration biased by aligned fibers or fiber-like geometries. First evidence of this phenomena was noted by Weiss36 in connective-tissue cells cultured on fibers, grooves or strand ...
and cells . Compared to biomolecules , EVs are present in subpicomolar concentrations, have a typical mass near a gigadalton, and diffuse 10- to 100-fold times slower than von Willebrand factor, the largest ...
for biological applications have enabled exploration and manipulation of biochemical phenomena in confined systems at the single cell level. Microfluidic devices are used to resemble the physicochemical events ...
phenomena of the biomolecule -membrane interaction in real time and, therefore, investigate the effects of lipid composition and phase on these interactions. It will give insights into our understanding of how ...
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