Abstract

The adrenergic blocking agent methyldopa (Aldomet) is toxic to C-1300 neuroblastoma cells in vivo . Four injections of Aldomet at a dose of 7.5 mg/injection were given over a period of 24 hr to C-1300 neuroblastoma-bearing mice. This treatment killed a significant proportion of the C-1300 neuroblastoma cells. Flow cytometric data suggest that sensitivity of tumor cells to Aldomet is not related to the cell cycle. 1 Supported by NIH-NINCDS-18413. 2 To whom requests for reprints should be addressed, at The University of Chicago, Department of Neurology, 950 E. 59th St., Chicago, Ill. 60637.