The Synthesis of 3,4-Benzpyrene-5-C14 and of 2-Acetylaminofluorene-9-C14
Abstract
The syntheses of two radioactive carcinogens of high specific activity are described in detail. 3,4-Benzpyrene-5-C 14 , specific activity 2.8 µc. per milligram, was obtained in over-all yield of 22 per cent, based on barium carbonate. 2-Acetylaminofluorene-9-C 14 , specific activity 4.55 µc. per milligram, was obtained in over-all yield of 50 per cent, based on barium carbonate. * An abstract of part of this report appeared in Cancer Research, 11:255, 1951. This work was supported in part by a grant from the Wisconsin Section of the American Cancer Society.