Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Influence of Tumor Volume and the Degree of Heating on the Response of the Solid Yoshida Sarcoma to Hyperthermia (40-42{degrees})

The Influence of Tumor Volume and the Degree of Heating on the Response of the Solid Yoshida... The solid Yoshida sarcoma implanted on the feet of rats was subjected to local hyperthermia by water bath immersion. Tumor response was governed by the temperature and duration of heating (i.e., the degree of heating) and by tumor volume. With small tumors (1.0- to 1.5-ml volume) an intratumor temperature of 42° maintained for 1 hr led to tumor regression in 11 to 13 days, and the tumor volume was halved every 2.6 days. Following 2 hr hyperthermia (42°) the tumors disappeared in 6 to 7 days, and tumor volume was halved every 1.2 days. Tumors of 2 to 3-ml volume had left the exponential phase of the growth curve and required 2 hr at 42° for cure. Following heating at 40° for 1 hr, there was a 50% increase in O 2 uptake and anaerobic CO 2 production by the tumor, accompanied by enhanced dissemination by lymphatic, vascular, and direct routes, and tumor was found in organs not usually the site of metastases ( e.g. , testis and stomach). With large tumors (3.0 to 4.5 ml), the survival time of the rats was significantly reduced. These results occurred in the absence of a rise in body temperature of the animals. It is concluded that in this animal-tumor system, hyperthermia at a temperature inadequate for tumor destruction (40°) can result in changes in the tumor that represent a hazard to the host. 1 The work was supported by the North of England Council of The Cancer Research Campaign. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

The Influence of Tumor Volume and the Degree of Heating on the Response of the Solid Yoshida Sarcoma to Hyperthermia (40-42{degrees})

Cancer Research , Volume 36 (3): 1188 – Mar 1, 1976

The Influence of Tumor Volume and the Degree of Heating on the Response of the Solid Yoshida Sarcoma to Hyperthermia (40-42{degrees})

Cancer Research , Volume 36 (3): 1188 – Mar 1, 1976

Abstract

The solid Yoshida sarcoma implanted on the feet of rats was subjected to local hyperthermia by water bath immersion. Tumor response was governed by the temperature and duration of heating (i.e., the degree of heating) and by tumor volume. With small tumors (1.0- to 1.5-ml volume) an intratumor temperature of 42° maintained for 1 hr led to tumor regression in 11 to 13 days, and the tumor volume was halved every 2.6 days. Following 2 hr hyperthermia (42°) the tumors disappeared in 6 to 7 days, and tumor volume was halved every 1.2 days. Tumors of 2 to 3-ml volume had left the exponential phase of the growth curve and required 2 hr at 42° for cure. Following heating at 40° for 1 hr, there was a 50% increase in O 2 uptake and anaerobic CO 2 production by the tumor, accompanied by enhanced dissemination by lymphatic, vascular, and direct routes, and tumor was found in organs not usually the site of metastases ( e.g. , testis and stomach). With large tumors (3.0 to 4.5 ml), the survival time of the rats was significantly reduced. These results occurred in the absence of a rise in body temperature of the animals. It is concluded that in this animal-tumor system, hyperthermia at a temperature inadequate for tumor destruction (40°) can result in changes in the tumor that represent a hazard to the host. 1 The work was supported by the North of England Council of The Cancer Research Campaign.

Loading next page...
 
/lp/american-association-of-cancer-research/the-influence-of-tumor-volume-and-the-degree-of-heating-on-the-1ex4TY0KxC

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Association of Cancer Research
Copyright
Copyright © 1976 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

The solid Yoshida sarcoma implanted on the feet of rats was subjected to local hyperthermia by water bath immersion. Tumor response was governed by the temperature and duration of heating (i.e., the degree of heating) and by tumor volume. With small tumors (1.0- to 1.5-ml volume) an intratumor temperature of 42° maintained for 1 hr led to tumor regression in 11 to 13 days, and the tumor volume was halved every 2.6 days. Following 2 hr hyperthermia (42°) the tumors disappeared in 6 to 7 days, and tumor volume was halved every 1.2 days. Tumors of 2 to 3-ml volume had left the exponential phase of the growth curve and required 2 hr at 42° for cure. Following heating at 40° for 1 hr, there was a 50% increase in O 2 uptake and anaerobic CO 2 production by the tumor, accompanied by enhanced dissemination by lymphatic, vascular, and direct routes, and tumor was found in organs not usually the site of metastases ( e.g. , testis and stomach). With large tumors (3.0 to 4.5 ml), the survival time of the rats was significantly reduced. These results occurred in the absence of a rise in body temperature of the animals. It is concluded that in this animal-tumor system, hyperthermia at a temperature inadequate for tumor destruction (40°) can result in changes in the tumor that represent a hazard to the host. 1 The work was supported by the North of England Council of The Cancer Research Campaign.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Mar 1, 1976

There are no references for this article.