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The Effect of Aflatoxin B1 on the Hepatic Structure and RNA Synthesis in Rats Fed a Diet Marginally Deficient in Choline

The Effect of Aflatoxin B1 on the Hepatic Structure and RNA Synthesis in Rats Fed a Diet... Aflatoxin, a potent hepatotoxin, causes rapid inhibition of RNA polymerase activitiy in isolated rat liver nuclei. Its hepatotoxicity is accompanied by an injury of periportal parenchymal cells. Rats fed a diet marginally deficient in choline are protected against the acutely toxic action of aflatoxin B 1 . This diet does not prevent the rapid inhibition of RNA polymerase or the changes in nucleolar morphology following the administration of aflatoxin B 1 . The diet does however largely prevent the proliferation of smooth endoplasmic reticulum and the necrosis of periportal parenchymal cells. The diet appears to offer the possibility of separating those changes in the liver associated with hepatotoxicity from those associated with hepatocarcinogenicity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

The Effect of Aflatoxin B1 on the Hepatic Structure and RNA Synthesis in Rats Fed a Diet Marginally Deficient in Choline

Cancer Research , Volume 33 (11): 2878 – Nov 1, 1973

The Effect of Aflatoxin B1 on the Hepatic Structure and RNA Synthesis in Rats Fed a Diet Marginally Deficient in Choline

Cancer Research , Volume 33 (11): 2878 – Nov 1, 1973

Abstract

Aflatoxin, a potent hepatotoxin, causes rapid inhibition of RNA polymerase activitiy in isolated rat liver nuclei. Its hepatotoxicity is accompanied by an injury of periportal parenchymal cells. Rats fed a diet marginally deficient in choline are protected against the acutely toxic action of aflatoxin B 1 . This diet does not prevent the rapid inhibition of RNA polymerase or the changes in nucleolar morphology following the administration of aflatoxin B 1 . The diet does however largely prevent the proliferation of smooth endoplasmic reticulum and the necrosis of periportal parenchymal cells. The diet appears to offer the possibility of separating those changes in the liver associated with hepatotoxicity from those associated with hepatocarcinogenicity.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1973 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Aflatoxin, a potent hepatotoxin, causes rapid inhibition of RNA polymerase activitiy in isolated rat liver nuclei. Its hepatotoxicity is accompanied by an injury of periportal parenchymal cells. Rats fed a diet marginally deficient in choline are protected against the acutely toxic action of aflatoxin B 1 . This diet does not prevent the rapid inhibition of RNA polymerase or the changes in nucleolar morphology following the administration of aflatoxin B 1 . The diet does however largely prevent the proliferation of smooth endoplasmic reticulum and the necrosis of periportal parenchymal cells. The diet appears to offer the possibility of separating those changes in the liver associated with hepatotoxicity from those associated with hepatocarcinogenicity.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Nov 1, 1973

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