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p53 Mutations Cluster at Codon 249 in Hepatitis B Virus-positive Hepatocellular Carcinomas from China

p53 Mutations Cluster at Codon 249 in Hepatitis B Virus-positive Hepatocellular Carcinomas from... DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53 , whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss. 1 Supported by Grant CA54557 (B. L. S.) from the National Cancer Institute. 2 To whom requests for reprints should be addressed, at the Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

p53 Mutations Cluster at Codon 249 in Hepatitis B Virus-positive Hepatocellular Carcinomas from China

p53 Mutations Cluster at Codon 249 in Hepatitis B Virus-positive Hepatocellular Carcinomas from China

Cancer Research , Volume 52 (6): 1635 – Mar 15, 1992

Abstract

DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53 , whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss. 1 Supported by Grant CA54557 (B. L. S.) from the National Cancer Institute. 2 To whom requests for reprints should be addressed, at the Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1992 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

DNA samples from 36 hepatocellular carcinoma (HCC) patients from China were screened for a specific mutation affecting codon 249 of the p53 gene, recently identified as a hotspot mutation in some HCCs. We detected the tumor-specific p53 codon 249 mutation in 21 (58%) of 36 HCCs examined. Thirteen patients with the specific codon 249 mutation had lost the remaining allele of p53 , whereas the remaining eight patients appeared to have retained both copies of the gene. These results suggest that alterations of p53 may be important events in the genesis of HCCs and that point mutation may precede allele loss. 1 Supported by Grant CA54557 (B. L. S.) from the National Cancer Institute. 2 To whom requests for reprints should be addressed, at the Division of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Mar 15, 1992

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