“Whoa! It’s like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Mutagenicity Induced by Hyperthermia, Hot Mate Infusion, and Hot Caffeine in Saccharomyces cerevisiae

Mate, an infusion containing caffeine (3 g/liter), is drunk hot by most Uruguayan, North Argentinian, and South Brazilian people. This beverage has been recently associated with esophageal cancer in Brazil and Uruguay. To test the mutagenic and lethal effects of mate infusion, caffeine, hyperthermia, and their combinations, we used Saccharomyces cerevisiae as an eucaryotic model system measuring lys to LYS reversions. We showed that mate infusion was not mutagenic, whereas caffeine at the same concentration contained in mate, produced a 5-fold increase in the spontaneous mutation rate. The highest observed mutagenic rate corresponded to hyperthermia (54°C at 60 min). Hot caffeine also produced a time-dependent mutagenic effect, whereas hot mate infusion determined a significantly lower mutagenic effect than hot caffeine. The differential lethality produced by the tested agents plays an important role in the expression of the induced mutagenic damage. Caffeine and mate infusion could decrease the mutagenic effect of hyperthermia through the channeling of part of the induced DNA lesions into an error-free repair pathway. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Mutagenicity Induced by Hyperthermia, Hot Mate Infusion, and Hot Caffeine in Saccharomyces cerevisiae

Abstract

Mate, an infusion containing caffeine (3 g/liter), is drunk hot by most Uruguayan, North Argentinian, and South Brazilian people. This beverage has been recently associated with esophageal cancer in Brazil and Uruguay. To test the mutagenic and lethal effects of mate infusion, caffeine, hyperthermia, and their combinations, we used Saccharomyces cerevisiae as an eucaryotic model system measuring lys to LYS reversions. We showed that mate infusion was not mutagenic, whereas caffeine at the same concentration contained in mate, produced a 5-fold increase in the spontaneous mutation rate. The highest observed mutagenic rate corresponded to hyperthermia (54°C at 60 min). Hot caffeine also produced a time-dependent mutagenic effect, whereas hot mate infusion determined a significantly lower mutagenic effect than hot caffeine. The differential lethality produced by the tested agents plays an important role in the expression of the induced mutagenic damage. Caffeine and mate infusion could decrease the mutagenic effect of hyperthermia through the channeling of part of the induced DNA lesions into an error-free repair pathway. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Loading next page...
1
 
/lp/american-association-of-cancer-research/mutagenicity-induced-by-hyperthermia-hot-mate-infusion-and-hot-xvkjAYk7tn

Sorry, we don’t have permission to share this article on DeepDyve,
but here are related articles that you can start reading right now:

Explore the DeepDyve Library

How DeepDyve Works

Spend time researching, not time worrying you’re buying articles that might not be useful.

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.

All the latest content is available, no embargo periods.

See the journals in your area

Simple and Affordable Pricing

14-day free trial. Cancel anytime, with a 30-day money-back guarantee.

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$40/month

Best Deal — 25% off

Annual Plan

  • All the features of the Professional Plan, but for 25% off!
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$30/month
billed annually