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Hydroxyurea and Escherichia coli Nucleoside Diphosphate Reductase

Hydroxyurea and Escherichia coli Nucleoside Diphosphate Reductase Upon removal of hydroxyurea, bacteria regained the ability to synthesize DNA. This occurred in the absence of concomitant protein production. The results indicate that irreversible inactivation of nucleoside diphosphate reductase followed by rapid regeneration of the enzyme upon removal of the drug is not the basis of the selective and reversible inhibition of DNA synthesis by hydroxyurea. 1 This investigation was supported by a grant from the Damon Runyon Memorial Fund for Cancer Research. 2 Research Career Development Awardee of the Division of General Medical Sciences, USPHS (5-K3-GM-29,024). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Hydroxyurea and Escherichia coli Nucleoside Diphosphate Reductase

Cancer Research , Volume 30 (7): 1926 – Jul 1, 1970

Hydroxyurea and Escherichia coli Nucleoside Diphosphate Reductase

Cancer Research , Volume 30 (7): 1926 – Jul 1, 1970

Abstract

Upon removal of hydroxyurea, bacteria regained the ability to synthesize DNA. This occurred in the absence of concomitant protein production. The results indicate that irreversible inactivation of nucleoside diphosphate reductase followed by rapid regeneration of the enzyme upon removal of the drug is not the basis of the selective and reversible inhibition of DNA synthesis by hydroxyurea. 1 This investigation was supported by a grant from the Damon Runyon Memorial Fund for Cancer Research. 2 Research Career Development Awardee of the Division of General Medical Sciences, USPHS (5-K3-GM-29,024).

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1970 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Upon removal of hydroxyurea, bacteria regained the ability to synthesize DNA. This occurred in the absence of concomitant protein production. The results indicate that irreversible inactivation of nucleoside diphosphate reductase followed by rapid regeneration of the enzyme upon removal of the drug is not the basis of the selective and reversible inhibition of DNA synthesis by hydroxyurea. 1 This investigation was supported by a grant from the Damon Runyon Memorial Fund for Cancer Research. 2 Research Career Development Awardee of the Division of General Medical Sciences, USPHS (5-K3-GM-29,024).

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Jul 1, 1970

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