Distribution of Injected I131-labeled Antibody to Dog Fibrin in Tumor-bearing Dogs
Abstract
Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I 131 content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I 131 . In a few instances preferential I 131 localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue. * This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York.