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Distribution of Injected I131-labeled Antibody to Dog Fibrin in Tumor-bearing Dogs

Distribution of Injected I131-labeled Antibody to Dog Fibrin in Tumor-bearing Dogs Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I 131 content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I 131 . In a few instances preferential I 131 localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue. * This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Distribution of Injected I131-labeled Antibody to Dog Fibrin in Tumor-bearing Dogs

Distribution of Injected I131-labeled Antibody to Dog Fibrin in Tumor-bearing Dogs

Cancer Research , Volume 20 (10 Part 1 ): 1501 – Nov 1, 1960

Abstract

Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I 131 content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I 131 . In a few instances preferential I 131 localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue. * This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1960 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I 131 content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I 131 . In a few instances preferential I 131 localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue. * This paper is based on work performed under contract with the U.S. Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Nov 1, 1960

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