Use of receiver operating characteristic curves to evaluate the clinical performance of analytical systems.

Use of receiver operating characteristic curves to evaluate the clinical performance of... Abstract The usefulness of an analytical system in patient care is ultimately judged not by its analytical performance but by its clinical performance, i.e., its ability to separate apparently similar patients into two subgroups, one of which has a particular clinically important condition and another subgroup which does not. This clinical performance can be studied with the tools of signal detectability theory, originally developed to analyze the performance of radar and data-transmission systems. Each classification made by an analytical system may be categorized as a true-positive, true-negative, false-positive, or false-negative decision. For laboratory tests the proportion of decisions in each category depends on the biological overlap between the two subgroups, the analytical performance of the system, and the decision level chosen. The clinical performance of the analytical system for all possible decision levels is represented by the receiver operating characteristic curve, which plots the true-positive rate against the false-positive rate. The use of these curves permits comparison of alternative analytical techniques at equal true-positive rates and at all possible decision levels. These comparisons show the effect of analytical improvements on clinical performance. © 1981 The American Association for Clinical Chemistry « Previous | Next Article » Table of Contents This Article Clinical Chemistry September 1981 vol. 27 no. 9 1569-1574 » Abstract PDF Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses No responses published Citing Articles Load citing article information Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Robertson, E. A. Articles by Zweig, M. H. Search for related content PubMed PubMed citation Articles by Robertson, E. A. Articles by Zweig, M. H. Related Content Load related web page information Follow Us Clinical Chemistry Trainee Council Register Today! www.traineecouncil.org Information for Authors Submit a Manuscript Editorial Board Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Journal Club Podcasts Translated Content Annual Meeting Abstracts Permissions and Reprints Advertising Copyright © 2012 by the American Association for Clinical Chemistry http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry American Association for Clinical Chemistry

Use of receiver operating characteristic curves to evaluate the clinical performance of analytical systems.

Clinical Chemistry, Volume 27 (9): 1569 – Sep 1, 1981

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Publisher
American Association for Clinical Chemistry
Copyright
Copyright © 1981 by the American Association for Clinical Chemistry.
ISSN
0009-9147
eISSN
1530-8561
Publisher site
See Article on Publisher Site

Abstract

Abstract The usefulness of an analytical system in patient care is ultimately judged not by its analytical performance but by its clinical performance, i.e., its ability to separate apparently similar patients into two subgroups, one of which has a particular clinically important condition and another subgroup which does not. This clinical performance can be studied with the tools of signal detectability theory, originally developed to analyze the performance of radar and data-transmission systems. Each classification made by an analytical system may be categorized as a true-positive, true-negative, false-positive, or false-negative decision. For laboratory tests the proportion of decisions in each category depends on the biological overlap between the two subgroups, the analytical performance of the system, and the decision level chosen. The clinical performance of the analytical system for all possible decision levels is represented by the receiver operating characteristic curve, which plots the true-positive rate against the false-positive rate. The use of these curves permits comparison of alternative analytical techniques at equal true-positive rates and at all possible decision levels. These comparisons show the effect of analytical improvements on clinical performance. © 1981 The American Association for Clinical Chemistry « Previous | Next Article » Table of Contents This Article Clinical Chemistry September 1981 vol. 27 no. 9 1569-1574 » Abstract PDF Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses No responses published Citing Articles Load citing article information Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Robertson, E. A. Articles by Zweig, M. H. Search for related content PubMed PubMed citation Articles by Robertson, E. A. Articles by Zweig, M. H. Related Content Load related web page information Follow Us Clinical Chemistry Trainee Council Register Today! www.traineecouncil.org Information for Authors Submit a Manuscript Editorial Board Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Journal Club Podcasts Translated Content Annual Meeting Abstracts Permissions and Reprints Advertising Copyright © 2012 by the American Association for Clinical Chemistry

Journal

Clinical ChemistryAmerican Association for Clinical Chemistry

Published: Sep 1, 1981

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