Estimation of True Calcium Absorption in Men

Estimation of True Calcium Absorption in Men Estimation of True Calcium Absorption in Men Robert P. Heaney 1 , a , Mary Susan Dowell 1 and Randi L. Wolf 2 1 Creighton University, Omaha, NE 68131 2 Teachers College, Columbia University, New York, NY 10027 ↵ a address correspondence to this author at: Creighton University, 601 N. 30th St., Suite 4841, Omaha, NE 68131; fax 402-280-4751, e-mail rheaney@creighton.edu When both calcium intake and calcium absorption are measured under controlled conditions, variation in absorption efficiency explains more of the interindividual differences in balance than does actual calcium intake ( 1 ). Small wonder, therefore, that interest in measuring absorption has remained high for nearly 40 years. True calcium absorption is defined as the quantitative, unidirectional flux of calcium from intestinal lumen into the blood. It is most accurately measured by a dual-tracer method, with one tracer labeling the oral calcium load and the other labeling the miscible calcium pool into which the absorbed calcium is introduced. This approach was first developed into a practicable human test by deGrazia et al. ( 2 ). As described, it is usually time-consuming and expensive. To reduce these barriers for widespread use, Heaney and Recker ( 3 )( 4 ) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry American Association for Clinical Chemistry

Estimation of True Calcium Absorption in Men

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Publisher
American Association for Clinical Chemistry
Copyright
Copyright © 2002 by the American Association for Clinical Chemistry.
ISSN
0009-9147
eISSN
1530-8561
Publisher site
See Article on Publisher Site

Abstract

Estimation of True Calcium Absorption in Men Robert P. Heaney 1 , a , Mary Susan Dowell 1 and Randi L. Wolf 2 1 Creighton University, Omaha, NE 68131 2 Teachers College, Columbia University, New York, NY 10027 ↵ a address correspondence to this author at: Creighton University, 601 N. 30th St., Suite 4841, Omaha, NE 68131; fax 402-280-4751, e-mail rheaney@creighton.edu When both calcium intake and calcium absorption are measured under controlled conditions, variation in absorption efficiency explains more of the interindividual differences in balance than does actual calcium intake ( 1 ). Small wonder, therefore, that interest in measuring absorption has remained high for nearly 40 years. True calcium absorption is defined as the quantitative, unidirectional flux of calcium from intestinal lumen into the blood. It is most accurately measured by a dual-tracer method, with one tracer labeling the oral calcium load and the other labeling the miscible calcium pool into which the absorbed calcium is introduced. This approach was first developed into a practicable human test by deGrazia et al. ( 2 ). As described, it is usually time-consuming and expensive. To reduce these barriers for widespread use, Heaney and Recker ( 3 )( 4 )

Journal

Clinical ChemistryAmerican Association for Clinical Chemistry

Published: May 1, 2002

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