Distribution and Correlates of C-Reactive Protein Concentrations among Adult US Women

Distribution and Correlates of C-Reactive Protein Concentrations among Adult US Women Abstract Background: Understanding the distribution of C-reactive protein (CRP) concentration among adult women in the US helps to establish the magnitude of women at increased risk for cardiovascular disease. Methods: We examined the distribution and correlates of CRP, using data from 2205 women ≥20 years of age from the National Health and Nutrition Examination Survey 1999–2000. CRP was measured with a high-sensitivity latex-enhanced turbidimetric assay. Results: CRP concentration ranged from 0.1 to 296.0 mg/L (median, 2.7 mg/L). After exclusion of women with a CRP concentration >10 mg/L, the median was 2.2 mg/L. Approximately 25.7% of women, representing ∼26.8 million women, did not report using hormone replacement therapy and had a CRP concentration >3.0 to 10 mg/L, a category considered to indicate high risk for cardiovascular disease. Multiple linear regression analysis included age, race or ethnicity, education, smoking status, total cholesterol concentration, triglyceride concentration, systolic blood pressure, waist circumference, and concentrations of glucose, insulin, c-peptide, and glycated hemoglobin. CRP concentration varied by race or ethnicity (Mexican American > white) and hormone replacement therapy (users > nonusers). In addition, significant and independent associations existed between CRP and waist circumference, total cholesterol and triglyceride concentrations, and systolic blood pressure but not age, smoking status, alcohol use, insulin concentration, glycated hemoglobin, and c-peptide concentration. Conclusion: Large numbers of US women have an increased concentration of CRP. © 2004 The American Association for Clinical Chemistry « Previous | Next Article » Table of Contents This Article Published January 6, 2004. doi: 10.1373/clinchem.2003.027359 Clinical Chemistry March 2004 vol. 50 no. 3 574-581 » Abstract Full Text PDF All Versions of this Article: clinchem.2003.027359v1 50/3/574 most recent Classifications Lipids, Lipoproteins, and Cardiovascular Risk Factors Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses No responses published Citing Articles Load citing article information Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Ford, E. S. Articles by Myers, G. L. Search for related content PubMed PubMed citation Articles by Ford, E. S. Articles by Myers, G. L. Related Collections Laboratory Management General Clinical Chemistry Lipids, Lipoproteins, and Cardiovascular Risk Factors Related Content Load related web page information Follow Us Clinical Chemistry Trainee Council Register Today! www.traineecouncil.org Information for Authors Submit a Manuscript Editorial Board Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Journal Club Podcasts Translated Content Annual Meeting Abstracts Permissions and Reprints Advertising Copyright © 2012 by the American Association for Clinical Chemistry http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry American Association for Clinical Chemistry

Distribution and Correlates of C-Reactive Protein Concentrations among Adult US Women

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Publisher
American Association for Clinical Chemistry
Copyright
Copyright © 2004 by the American Association for Clinical Chemistry.
ISSN
0009-9147
eISSN
1530-8561
D.O.I.
10.1373/clinchem.2003.027359
Publisher site
See Article on Publisher Site

Abstract

Abstract Background: Understanding the distribution of C-reactive protein (CRP) concentration among adult women in the US helps to establish the magnitude of women at increased risk for cardiovascular disease. Methods: We examined the distribution and correlates of CRP, using data from 2205 women ≥20 years of age from the National Health and Nutrition Examination Survey 1999–2000. CRP was measured with a high-sensitivity latex-enhanced turbidimetric assay. Results: CRP concentration ranged from 0.1 to 296.0 mg/L (median, 2.7 mg/L). After exclusion of women with a CRP concentration >10 mg/L, the median was 2.2 mg/L. Approximately 25.7% of women, representing ∼26.8 million women, did not report using hormone replacement therapy and had a CRP concentration >3.0 to 10 mg/L, a category considered to indicate high risk for cardiovascular disease. Multiple linear regression analysis included age, race or ethnicity, education, smoking status, total cholesterol concentration, triglyceride concentration, systolic blood pressure, waist circumference, and concentrations of glucose, insulin, c-peptide, and glycated hemoglobin. CRP concentration varied by race or ethnicity (Mexican American > white) and hormone replacement therapy (users > nonusers). In addition, significant and independent associations existed between CRP and waist circumference, total cholesterol and triglyceride concentrations, and systolic blood pressure but not age, smoking status, alcohol use, insulin concentration, glycated hemoglobin, and c-peptide concentration. Conclusion: Large numbers of US women have an increased concentration of CRP. © 2004 The American Association for Clinical Chemistry « Previous | Next Article » Table of Contents This Article Published January 6, 2004. doi: 10.1373/clinchem.2003.027359 Clinical Chemistry March 2004 vol. 50 no. 3 574-581 » Abstract Full Text PDF All Versions of this Article: clinchem.2003.027359v1 50/3/574 most recent Classifications Lipids, Lipoproteins, and Cardiovascular Risk Factors Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Responses No responses published Citing Articles Load citing article information Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Ford, E. S. Articles by Myers, G. L. Search for related content PubMed PubMed citation Articles by Ford, E. S. Articles by Myers, G. L. Related Collections Laboratory Management General Clinical Chemistry Lipids, Lipoproteins, and Cardiovascular Risk Factors Related Content Load related web page information Follow Us Clinical Chemistry Trainee Council Register Today! www.traineecouncil.org Information for Authors Submit a Manuscript Editorial Board Clinical Case Studies Clinical Chemistry Guide to Scientific Writing Journal Club Podcasts Translated Content Annual Meeting Abstracts Permissions and Reprints Advertising Copyright © 2012 by the American Association for Clinical Chemistry

Journal

Clinical ChemistryAmerican Association for Clinical Chemistry

Published: Mar 1, 2004

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