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Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia

Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia — Molecular Pharmacology var callbackToken='4731D570BC302F8'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia George R. Dubyak Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio George Dubyak, Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106. E-mail: gxd3@po.cwru.edu ATP, UTP, and their corresponding disphosphates function as intercellular signaling molecules when released to, or generated within, extracellular compartments. Genes encoding eight G protein-coupled P2Y nucleotide receptor subtypes ( von Kugelgen and Wetter, 2000 ), seven ionotropic P2X nucleotide receptor subtypes ( North, 2002 ), and at least nine different ecto-nucleotidases ( Zimmermann, 2000 ) have been identified in human and other vertebrate genomes. Most mammalian cell types express one or more subtypes of nucleotide receptor together with various combinations of the ecto-nucleotidases used for degrading and/or interconverting extracellular nucleotides. In this issue of Molecular Pharmacology , Robaye et al. (2003) describe the generation and initial phenotypic characterization of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Pharmacology Am. Soc for Pharma & Experimental Therapeutics

Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia

Abstract

Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia — Molecular Pharmacology var callbackToken='4731D570BC302F8'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Knock-Out Mice Reveal Tissue-Specific Roles of P2Y Receptor Subtypes in Different Epithelia George R. Dubyak Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio George Dubyak, Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106. E-mail: gxd3@po.cwru.edu ATP, UTP, and their corresponding disphosphates function as intercellular signaling molecules when released to, or generated within, extracellular compartments. Genes encoding eight G protein-coupled P2Y nucleotide receptor subtypes ( von Kugelgen and Wetter, 2000 ), seven ionotropic P2X nucleotide receptor subtypes ( North, 2002 ), and at least nine different ecto-nucleotidases ( Zimmermann, 2000 ) have been identified in human and other vertebrate genomes. Most mammalian cell types express one or more subtypes of nucleotide receptor together with various combinations of the ecto-nucleotidases used for degrading and/or interconverting extracellular nucleotides. In this issue of Molecular Pharmacology , Robaye et al. (2003) describe the generation and initial phenotypic characterization of
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