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GIRK Channel Trafficking: Different Paths for Different Family Members

GIRK Channel Trafficking: Different Paths for Different Family Members Abstract Ma et al. have reported that different G protein-regulated inwardly rectifying K + (GIRK) channels composed of combinations of Kir3.1-Kir3.2-Kir3.3-Kir3.4 are localized to different subcellular compartments. Kir3.3 seems to target Kir3.1-containing channels to lysosomes, whereas Kir3.1-containing channels also consisting of Kir3.2 or Kir3.4 are successfully expressed at the cell surface. The new results suggest a mechanism whereby the surface expression of heterotetramers is controlled and thus channel density can be properly maintained. Mirshahi and Logothetis discuss the results and their implications for channel trafficking, but caution that we are far from understanding the whole regulatory process and that, indeed, other mechanisms participate in maintaining channel density. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Interventions Am. Soc for Pharma & Experimental Therapeutics

GIRK Channel Trafficking: Different Paths for Different Family Members

GIRK Channel Trafficking: Different Paths for Different Family Members

Molecular Interventions , Volume 2 (5): 289 – Sep 1, 2002

Abstract

Abstract Ma et al. have reported that different G protein-regulated inwardly rectifying K + (GIRK) channels composed of combinations of Kir3.1-Kir3.2-Kir3.3-Kir3.4 are localized to different subcellular compartments. Kir3.3 seems to target Kir3.1-containing channels to lysosomes, whereas Kir3.1-containing channels also consisting of Kir3.2 or Kir3.4 are successfully expressed at the cell surface. The new results suggest a mechanism whereby the surface expression of heterotetramers is controlled and thus channel density can be properly maintained. Mirshahi and Logothetis discuss the results and their implications for channel trafficking, but caution that we are far from understanding the whole regulatory process and that, indeed, other mechanisms participate in maintaining channel density.

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Publisher
Am. Soc for Pharma & Experimental Therapeutics
Copyright
Copyright © Molecular Interventions
ISSN
1534-0384
eISSN
1543-2548
DOI
10.1124/mi.2.5.289
pmid
14993383
Publisher site
See Article on Publisher Site

Abstract

Abstract Ma et al. have reported that different G protein-regulated inwardly rectifying K + (GIRK) channels composed of combinations of Kir3.1-Kir3.2-Kir3.3-Kir3.4 are localized to different subcellular compartments. Kir3.3 seems to target Kir3.1-containing channels to lysosomes, whereas Kir3.1-containing channels also consisting of Kir3.2 or Kir3.4 are successfully expressed at the cell surface. The new results suggest a mechanism whereby the surface expression of heterotetramers is controlled and thus channel density can be properly maintained. Mirshahi and Logothetis discuss the results and their implications for channel trafficking, but caution that we are far from understanding the whole regulatory process and that, indeed, other mechanisms participate in maintaining channel density.

Journal

Molecular InterventionsAm. Soc for Pharma & Experimental Therapeutics

Published: Sep 1, 2002

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