Abstract

Contribution of the Extracellular cAMP-Adenosine Pathway to Dual Coupling of β2-Adrenoceptors to Gs and Gi Proteins in Mouse Skeletal Muscle var callbackToken='50585A31347A73B'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Contribution of the Extracellular cAMP-Adenosine Pathway to Dual Coupling of β 2 -Adrenoceptors to G s and G i Proteins in Mouse Skeletal Muscle Thiago Duarte , Francisco Sandro Menezes-Rodrigues and Rosely Oliveira Godinho Division of Cellular Pharmacology, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil <h3>Address correspondence to:</h3> Dr. Rosely Oliveira Godinho, Department of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Três de Maio, 100 São Paulo, SP Brazil 04044-020. E-mail: godinho@unifesp.br <h2>Abstract</h2> β 2 -Adrenoceptor (β 2 -AR) agonists increase skeletal muscle contractile force via activation of G s protein/adenylyl cyclases (AC) and increased generation of cAMP. Herein, we evaluated the possible dual coupling of β 2 -AR to G s and G i proteins and the influence of the β 2 -AR/G s -G i /cAMP signaling cascade on skeletal muscle contraction.