-
Jean
Wang,
W.
Edelmann
(2006)
Mismatch repair proteins as sensors of alkylation DNA damage.
Cancer cell, 9 6
-
J.
Jiricny
(2006)
The multifaceted mismatch-repair system
Nature Reviews Molecular Cell Biology, 7
-
P.
Vernole,
R.
Pepponi,
S.
D’Atri
(2003)
Role of mismatch repair in the induction of chromosomal aberrations and sister chromatid exchanges in cells treated with different chemotherapeutic agents
Cancer Chemotherapy and Pharmacology, 52
-
(2003)
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G 2 checkpoint and to resistance to chemotherapeutic DNAmethylating agents
-
W.
Roos,
B.
Kaina
(2006)
DNA damage-induced cell death by apoptosis.
Trends in molecular medicine, 12 9
-
Lovorka
Stojic,
R.
Brun,
J.
Jiricny
(2004)
Mismatch repair and DNA damage signalling.
DNA repair, 3 8-9
-
K.
West,
S.
Castillo,
P.
Dennis
(2002)
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 5 6
-
Victor
GoldmacherS,
Robert
Cuzick,
William
Thillyll
(1986)
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.
The Journal of biological chemistry, 261 27
-
Y.
Hirose,
M.
Katayama,
D.
Stokoe,
D.
Haas-Kogan,
M.
Berger,
R.
Pieper
(2003)
The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents
Molecular and Cellular Biology, 23
-
A.
Sabharwal,
M.
Middleton
(2006)
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy.
Current opinion in pharmacology, 6 4
-
S.
Matsuoka,
B.
Ballif,
A.
Smogorzewska,
A.
Smogorzewska,
E.
McDonald,
Kristen
Hurov,
Ji
Luo,
C.
Bakalarski,
Zhenming
Zhao,
N.
Solimini,
Y.
Lerenthal,
Y.
Shiloh,
S.
Gygi,
S.
Elledge
(2007)
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Science, 316
-
D.
Alessi,
M.
Andjelkovic,
Barry
Caudwell,
P.
Cron,
N.
Morrice,
P.
Cohen,
B.
Hemmings
(1996)
Mechanism of activation of protein kinase B by insulin and IGF‐1.
The EMBO Journal, 15
-
N.
Papadopoulos,
N.
Nicolaides,
Bo
Liu,
Ramon
Parsons,
C.
Lengauer,
F.
Palombo,
A.
D’Arrigo,
S.
Markowitz,
J.
Willson,
K.
Kinzler,
J.
Jiricny,
B.
Vogelstein
(1995)
Mutations of GTBP in genetically unstable cells.
Science, 268 5219
-
Lily
Dong,
Feng
Liu
(2005)
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
American journal of physiology. Endocrinology and metabolism, 289 2
-
Y.
Hirose,
M.
Katayama,
O.
Mirzoeva,
M.
Berger,
R.
Pieper
(2005)
Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence.
Cancer research, 65 11
-
Jianhua
Feng,
Jongsun
Park,
P.
Cron,
D.
Hess,
B.
Hemmings
(2004)
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase*♦
Journal of Biological Chemistry, 279
-
M.
Bignami,
M.
O’Driscoll,
G.
Aquilina,
P.
Karran
(2000)
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents.
Mutation research, 462 2-3
-
(2005)
Activation of AKT
-
Address correspondence to: Dr. Stefania D'Atri, Istituto Dermopatico Dell'Immacolata (IDI-IRCCS), Via dei Monti di Creta 104
-
M.
Clemons,
J.
Kelly,
A.
Watson,
A.
Howell,
R.
Mcelhinney,
T.
Mcmurry,
G.
Margison
(2005)
O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts
British Journal of Cancer, 93
-
C.
Rabik,
Maria
Njoku,
M.
Dolan
(2006)
Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
Cancer treatment reviews, 32 4
-
(2006)
Exploiting the role
-
A.
Bellacosa,
C.
Kumar,
A.
Cristofano,
J.
Testa
(2005)
Activation of AKT kinases in cancer: implications for therapeutic targeting.
Advances in cancer research, 94
-
V.
O’Brien,
Robert
Brown
(2006)
Signalling cell cycle arrest and cell death through the MMR System.
Carcinogenesis, 27 4
-
N.
Papadopoulos,
N.
Nicolaides,
Y.
Wei,
S.
Ruben,
K.
Carter,
C.
Rosen,
W.
Haseltine,
R.
Fleischmann,
C.
Fraser,
Mark
Adams,
J.
Venter,
S.
Hamilton,
G.
Petersen,
P.
Watson,
H.
Lynch,
P.
Peltomäki,
J.
Mecklin,
A.
Chapelle,
K.
Kinzler,
B.
Vogelstein
(1994)
Mutation of a mutL homolog in hereditary colon cancer.
Science, 263 5153
-
T.
Franke,
Sung‐Il
Yang,
T.
Chan,
K.
Datta,
A.
Kazlauskas,
D.
Morrison,
D.
Kaplan,
P.
Tsichlis
(1995)
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
Cell, 81
-
Lovorka
Stojic,
N.
Mojas,
P.
Cejka,
M.
Pietro,
S.
Ferrari,
G.
Marra,
J.
Jiricny
(2004)
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
Genes & development, 18 11
-
R.
Fishel
(1999)
Signaling mismatch repair in cancer
Nature Medicine, 5
-
M.
Payne,
S.
Pratap,
M.
Middleton
(2005)
Temozolomide in the treatment of solid tumours: current results and rationale for dosing/scheduling.
Critical reviews in oncology/hematology, 53 3
-
Courtney
Granville,
R.
Memmott,
Joell
Gills,
P.
Dennis
(2006)
Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway
Clinical Cancer Research, 12
-
A.
Kozikowski,
Haiying
Sun,
J.
Brognard,
P.
Dennis
(2003)
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.
Journal of the American Chemical Society, 125 5
-
(2007)
O6-alkylguanine-DNA alkyltransferase. Carcinogenesis
-
M.
Yamada,
Keiko
Tanabe,
K.
Wada,
K.
Shimoke,
Y.
Ishikawa,
T.
Ikeuchi,
S.
Koizumi,
H.
Hatanaka
(2001)
Differences in survival‐promoting effects and intracellular signaling properties of BDNF and IGF‐1 in cultured cerebral cortical neurons
Journal of Neurochemistry, 78
-
S.
D’Atri,
L.
Tentori,
P.
Lacal,
G.
Graziani,
E.
Pagani,
Elena
Benincasa,
Giovanna
Zambruno,
Enzo
Bonmassar,
Josef
Jiricny
(1998)
Involvement of the mismatch repair system in temozolomide-induced apoptosis.
Molecular pharmacology, 54 2
-
S.
Caporali,
S.
Falcinelli,
G.
Starace,
M.
Russo,
E.
Bonmassar,
J.
Jiricny,
S.
D’Atri
(2004)
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.
Molecular pharmacology, 66 3
-
(2000)
Unmasking a killer: DNA
-
C.
Bakkenist,
M.
Kastan
(2004)
Initiating Cellular Stress Responses
Cell, 118
-
S.
Gerson
(2002)
Clinical relevance of MGMT in the treatment of cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 9
-
M.
Koi,
A.
Umar,
D.
Chauhan,
Sajeev
Cherian,
J.
Carethers,
T.
Kunkel,
C.
Boland
(1994)
Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.
Cancer research, 54 16
-
Bernd
Kaina,
Aliki
Ziouta,
K.
Ochs,
T.
Coquerelle
(1997)
Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models.
Mutation research, 381 2
-
(2003)
Variability and regulation
-
A.
Toker,
A.
Newton
(2000)
Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site*
The Journal of Biological Chemistry, 275
-
E-mail: s.datri@idi
-
(2004)
Mismatch repair and DNA damage signaling. DNA Repair (Amst) 3:1091–1101
-
D.
Sarbassov,
D.
Guertin,
Siraj
Ali,
D.
Sabatini
(2005)
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
Science, 307
-
J.
Viniegra,
N.
Martínez,
Pegah
Modirassari,
J.
Losa,
C.
Cobo,
V.
Lobo,
C.
Luquero,
L.
Álvarez-Vallina,
S.
Cajal,
J.
Rojas,
R.
Sánchez-Prieto
(2005)
Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM*
Journal of Biological Chemistry, 280
-
J Biol Chem
-
E.
Newlands,
M.
Stevens,
S.
Wedge,
R.
Wheelhouse,
C.
Brock
(1997)
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials.
Cancer treatment reviews, 23 1
-
M.
Scheid,
P.
Marignani,
J.
Woodgett
(2002)
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B
Molecular and Cellular Biology, 22
-
G.
Margison,
A.
Povey,
B.
Kaina,
M.
Koref
(2003)
Variability and regulation of O6-alkylguanine-DNA alkyltransferase.
Carcinogenesis, 24 4