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A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice

A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice var callbackToken='4750122696A8DEF'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice Nathan C. Ni , Dong Yan , Laurel L. Ballantyne , Alma Barajas-Espinosa , Tim St. Amand , Derek A. Pratt and Colin D. Funk Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada (N.C.N., D.Y., L.L.B., A.B.-E., T.S.A., C.D.F.); and Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada (D.A.P.) <h3>Address correspondence to:</h3> Dr. Colin D. Funk, Queen's University, Botterell Hall, Room 433, 18 Stuart St., Kingston, Ontario, Canada, K7L 3N6. E-mail: funkc@queensu.ca N.C.N. and D.Y. contributed equally to this work. <h2>Abstract</h2> Cysteinyl leukotrienes (CysLTs) are potent inflammatory mediators that predominantly exert their effects by binding to cysteinyl leukotriene receptors of the G protein-coupled receptor family. CysLT receptor 2 (CysLT 2 R), expressed in endothelial cells of some vascular beds, has been implicated in a variety of cardiovascular functions. Endothelium-specific overexpression http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmacology and Experimental Therapeutics Am. Soc for Pharma & Experimental Therapeutics

A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice

Abstract

A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice var callbackToken='4750122696A8DEF'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice Nathan C. Ni , Dong Yan , Laurel L. Ballantyne , Alma Barajas-Espinosa , Tim St. Amand , Derek A. Pratt and Colin D. Funk Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada (N.C.N., D.Y., L.L.B., A.B.-E., T.S.A., C.D.F.); and Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada (D.A.P.) <h3>Address correspondence to:</h3> Dr. Colin D. Funk, Queen's University, Botterell Hall, Room 433, 18 Stuart St., Kingston, Ontario, Canada, K7L 3N6. E-mail: funkc@queensu.ca N.C.N. and D.Y. contributed equally to this work. <h2>Abstract</h2> Cysteinyl leukotrienes (CysLTs) are potent inflammatory mediators that predominantly exert their effects by binding to cysteinyl leukotriene receptors of the G protein-coupled receptor family. CysLT receptor 2 (CysLT 2 R), expressed in endothelial cells of some vascular beds, has been implicated in a variety of cardiovascular functions. Endothelium-specific overexpression
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