TY - JOUR
AU1 - Kim, Song
AU2 - Kim, Jungho
AU3 - Kim, Deok
AU4 - Kang, Young
AU5 - Bong, Sungyoung
AU6 - Lee, Jonghee
AU7 - Kim, Suyeon
AU8 - Lee, Nam
AU9 - Sim, Bora
AU1 - Cho, Sang-Nae
AU1 - Kim, Young
AU1 - Lee, Hyejon
AB - Background: Prior to clinical trials of new TB drugs or therapeutic vaccines, it is necessary to develop monitoring tools to predict treatment outcomes in TB patients. Urine interferon gamma inducible protein 10 (IP-10) is a potential biomarker of treatment response in chronic hepatitis C virus infection and lung diseases, including tuberculosis. In this study, we assessed IP-10 levels in urine samples from patients with active TB at diagnosis, during treatment, and at completion, and compared these with levels in serum samples collected in parallel from matched patients to determine whether urine IP-10 can be used to monitor treatment response in patients with active TB. Methods: IP-10 was measured using enzyme-linked immunosorbent assays in urine and serum samples collected concomitantly from 23 patients with active TB and 21 healthy adults (44 total individuals). The Mann-Whitney U test and Wilcoxon matched-pairs signed rank test were used for comparisons among healthy controls and patients at three time points, and LOESS regression was used for longitudinal data. Results: The levels of IP-10 in urine increased significantly after 2 months of treatment (P = 0.0163), but decreased by the completion of treatment (P = 0.0035). Serum IP-10 levels exhibited a similar trend, but did 
TI - Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis
JF - BMC Infectious Diseases
DO - 10.1186/s12879-018-3144-3
DA - 2018-05-29
UR - https://www.deepdyve.com/lp/springer-journals/urine-ip-10-as-a-biomarker-of-therapeutic-response-in-patients-with-zIYRX9lPU4
SP - 1
EP - 6
VL - 18
IS - 1
DP - DeepDyve
ER -