TY - JOUR
AU1 - Luo, Yanji
AU2 - Chen, Jie
AU3 - Shen, Bingqi
AU4 - Wang, Meng
AU5 - Cai, Huasong
AU6 - Xu, Ling
AU7 - Chen, Luohai
AU8 - Chen, Minhu
AU9 - Li, Zi-Ping
AU1 - Feng, Shi-Ting
AB - Objective To identify a reliable early indicator of deriving progression-free survival (PFS) benefit in patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with octreotide long-acting repeatable (LAR). Methods We investigated the images of 50 patients with well-differentiated advanced GEP-NETs treated with LAR octreotide and underwent baseline and follow-up thoracic, abdominal, and pelvic computed tomography. Receiver-operating characteristic (ROC) analysis and the Kaplan-Meier method were used to identify the optimal threshold to distinguish between those with and without significant improvement of PFS. Results The optimal threshold for determining a response to octreotide LAR was -10% ΔSLD, with a sensitivity and specificity of 85.7% and 80%, respectively. At this threshold, 19 patients were responders and 31 were non-responders; the median PFS was 20.2 and 7.6 months in responders and non-responders (hazard ratio, 2.66; 95% confidence interval, 1.32–5.36). Conclusion A 10% shrinkage in tumor size is an optimal early predictor of response to octreotide LAR in advanced GEP-NETs. Key points � Octreotide LAR can significantly prolong PFS among patients with well-differentiated advanced GEP-NETs. � No optimal tumor size-based response criteria are reported in GEP-NETs with octreotide. � Ten percent tumor shrinkage is a reliable indicator of the response to octreotide for advanced GEP-NETs. 
TI - CT evaluation of response in advanced gastroenteropancreatic neuroendocrine tumors treated with long-acting-repeatable octreotide: what is the optimal size variation threshold?
JF - European Radiology
DO - 10.1007/s00330-018-5512-1
DA - 2018-06-06
UR - https://www.deepdyve.com/lp/springer-journals/ct-evaluation-of-response-in-advanced-gastroenteropancreatic-k0dW09NGy2
SP - 5250
EP - 5257
VL - 28
IS - 12
DP - DeepDyve
ER -