TY - JOUR
AU1 - Williams-Gray, C.
AU2 - Wijeyekoon, R.
AU3 - Scott, K.
AU4 - Hayat, S.
AU5 - Barker, R.
AU6 - Jones, J.
AB - Background: A wealth of evidence implicates both central and peripheral immune changes as contributing to the pathogenesis of Parkinson’s disease (PD). It is critical to better understand this aspect of PD given that it is a tractable target for disease-modifying therapy. Age-related changes are known to occur in the immune system (immunosenescence) and might be of particular relevance in PD given that its prevalence rises with increasing age. We therefore sought to investigate this with respect to T cell replicative senescence, a key immune component of human ageing. Methods: Peripheral blood mononuclear cells were extracted from blood samples from 41 patients with mild PD (Hoehn and Yahr stages 1–2, mean (SD) disease duration 4.3 (1.2) years) and 41 age- and gender-matched controls. Immunophenotyping was performed with flow cytometry using markers of T lymphocyte activation and senescence (CD3, CD4, CD8, HLA-DR, CD38, CD28, CCR7, CD45RA, CD57, CD31). Cytomegalovirus (CMV) serology was measured given its proposed relevance in driving T cell senescence. Results: Markers of replicative senescence in the CD8+ population were strikingly reduced in PD cases versus controls (reduced CD57 expression (p = 0.005), reduced percentage of ‘late differentiated’ CD57 CD28 cells lo hi (p = 0.007) and ‘TEMRA’ cells 
TI - Abnormalities of age-related T cell senescence in Parkinson’s disease
JF - Journal of Neuroinflammation
DO - 10.1186/s12974-018-1206-5
DA - 2018-05-28
UR - https://www.deepdyve.com/lp/springer-journals/abnormalities-of-age-related-t-cell-senescence-in-parkinson-s-disease-WHHcyVw3T2
SP - 1
EP - 8
VL - 15
IS - 1
DP - DeepDyve