TY - JOUR
AU1 - Kurtoğlu, Ayşegül Uğur
AU2 - Karakuş, Volkan
AU3 - Kurtoğlu, Erdal
AU4 - Bozkurt, Selen
AB - AbstractIntroductionHeart failure due to hemosiderosis is frequent in beta-thalassemia major (β-TM) patients. Magnetic resonance imaging (MRI) is used in the early detection of heart failure. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a very sensitive marker in the diagnosis of heart failure. In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2*>20 msn), in early identification of cardiac failure.MethodsNT-proBNP levels of 31 patients, who have T2*>20 ms, and of 25 healthy population were measured by chemoluminescence method.ResultsNT-proBNP levels were not different in thalassemic patients [median: 33 (IQR: 28–94) pg/mL] compared to control group [median: 41 (IQR: 28–59) pg/mL]. We found that NT-proBNP level was above cut-off value in six patients.ConclusionNT-proBNP is a cheaper, reachable, and noninvasive method compared to MRI technique, it can be easily used in monthly controls. Detection of high NT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NT-pro-BNP is a more sensitive marker in early detection of cardiac failure.
TI - NT-proBNP levels in β-thalassemia major patients without cardiac hemosiderosis
JF - Turkish Journal of Biochemistry
DO - 10.1515/tjb-2016-0272
DA - 2017-02-01
UR - https://www.deepdyve.com/lp/de-gruyter/nt-probnp-levels-in-thalassemia-major-patients-without-cardiac-VimE0gNvkB
SP - 71
EP - 75
VL - 42
IS - 1
DP - DeepDyve
ER -