TY - JOUR
AU1 - DeGracia, Donald
AB - In this mini-review we give an overview of the role of mRNA-binding proteins and their associated messenger ribonucleoprotein complexes (mRNPs) in several disease states, and bring this information to bear on the pathophysiology of brain ischemia. One conclusion reached is that mRNPs may play a causal role in proteotoxicity instead of being merely passive targets. Ischemia therapies targeting mRNPs have advantages over targeting single pathways, but the behavior of mRNPs needs to be considered in the design of therapies.
TI - Disease of mRNA Regulation: Relevance for Ischemic Brain Injury
JF - Translational Stroke Research
DO - 10.1007/s12975-017-0586-7
DA - 2017-11-10
UR - https://www.deepdyve.com/lp/springer-journals/disease-of-mrna-regulation-relevance-for-ischemic-brain-injury-UWXEoimzBn
SP - 251
EP - 257
VL - 9
IS - 3
DP - DeepDyve