TY - JOUR AU1 - Sloberg, Kent AU2 - Hersle, Kjell AU3 - Mobacken, Håkan AU4 - Thilander, Holger AB - Abstract The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P<.05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P <.001). Irritation from tretinoin occurs and thorough usage information is mandatory. (Arch Dermatol 115:716-718, 1979). References 1. Samman PD: Lichen planus and lichenoid eruptions , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology , ed 2. Oxford, England, Blackwell Scientific Publications, 1972, pp 1334-1346. 2. DeLuca HF, Zile M: Aspects of teratology of vitamin A acid (β-all-trans retinoic acid) . Acta Derm Venereol 75( (suppl 74) ):13-20, 1975. 3. Zbinden G: Pharmacology of vitamin A acid (β-all-transretinoic acid) . Acta Derm Venereol 75( (suppl 74) ):21-24, 1975. 4. Christophers E, Wolff HH: Effects of vitamin A acid in skin: In vivo and in vitro studies . Acta Derm Venereol 75( (suppl 74) ):42-49, 1975. 5. Ryssel HJ, Brunner KW, Bollag W: Die peroorale Anwendung von Vitamin A Säure bei Leukoplakien Hyperkeratosen und Plattenepitelkarzinomen: Ergebnisse und Verträglichkeit . Schweiz Med Wochenschr 101:1027-1030, 1971. 6. Stüttgen G: Zur Lokalbehandlung von Keratosen mit Vitamin A-Säure . Dermatologica 124:65-80, 1962.Crossref 7. Kligman AM, Fulton JE, Plewig G: Topical vitamin A acid in acne vulgaris . Arch Dermatol 99:469-476, 1969.Crossref 8. Frost P, Weinstein GD: Topical administration of vitamin A acid for ichtyosiform dermatoses and psoriasis . JAMA 207:1863-1868, 1969.Crossref 9. Stüttgen G: Oral vitamin A acid therapy . Acta Derm Venereol 75( (suppl 74) ):174-179, 1975. 10. Günther S: Vitamin A acid in treatment of oral lichen planus . Arch Dermatol 107:277, 1973.Crossref 11. Ebner H, Mischer P, Raff M: Lokalbehandlung des Lichen ruber planus der Mundschleimhaut mit Vitamin-A-Säure . Z Hautkr 48:735-740, 1973. 12. Günther S: Über Wirksamkeit der Vitamin-A-Säure bei Erkrankungen der Mundschleimhaut: Lichen ruber planus, Leukoplakien und Lingua geographica . Z Hautkr 50:41-46, 1975. 13. Günther S: The therapeutic value of retinoic acid (vitamin A acid) in lichen planus of the oral mucous membranes . Dermatologica 147:130-136, 1973.Crossref 14. Shklar G: Erosive and bullous oral lesions of lichen planus: Histologic studies . Arch Dermatol 97:411-416, 1968.Crossref 15. Rogers RS III, Jordon RE: Immunopathology of oral mucosal inflammatory diseases . Clin Exp Dermatol 2:97-107, 1977.Crossref 16. Andreasen JO: Oral lichen planus: I. A clinical evaluation of 115 cases . Oral Surg 25:31-42, 1968.Crossref 17. Scheiber W, Plewig G: Behandlung des Lichen ruber mucosae mit Vitamin-A-Säure-Derivaten . Dermatologica 157:171-180, 1978.Crossref 18. Schaefer H, Zesch A: Penetration of vitamin A acid into human skin . Acta Derm Venereol 75 ( (suppl 74) ):50-55, 84, 1975. 19. Kligman AM, Mills OH Jr, Leyden JJ: Acne vulgaris: A treatable disease . Postgrad Med 55:99-105, 1974. 20. Wilkinson DJ: Effect of vitamin A acid on the growth of keratinocytes in culture . Arch Dermatol Res 263:75-81, 1978.Crossref 21. Kurka M, Orfanos CE, Pullman H: Vitamin-A-Säure zur Lokalbehandlung epithelialer Neoplasien . Hautarzt 29:313-318, 1978. 22. Bollag W: In general discussion of the International Symposium on the Therapeutic Use of Vitamin A Acid, Switzerland 1975 . Acta Derm Venereol 75( (suppl 74) ):184, 1975. TI - Topical Tretinoin Therapy and Oral Lichen Planus JF - Archives of Dermatology DO - 10.1001/archderm.1979.04010060024021 DA - 1979-06-01 UR - https://www.deepdyve.com/lp/american-medical-association/topical-tretinoin-therapy-and-oral-lichen-planus-U5JP6NZ1iE SP - 716 EP - 718 VL - 115 IS - 6 DP - DeepDyve ER -