TY - JOUR
AU1 - SMITH, HUGO DUNLAP
AU2 - KING, LIONEL R.
AU3 - MARGOLIN, E. GORDON
AB - Abstract LEAD encephalopathy continues to have a case fatality rate of approximately 25% and to cause damage to the central nervous system in over one half of the survivors.1 The mechanisms by which lead is toxic to the body and causes encephalopathy are not fully understood. In the average case of pediatric lead poisoning, the total amount of lead stored in the body is in the range of 250 to 1,200 mg.2 Of this amount, 20 to 100 mg are extraskeletal, located in the blood and soft tissues.3 Furthermore, in untreated patients dying with lead encephalopathy, the concentration of lead in the brain is no less than 0.2 mg of lead per 100 gm of brain tissue.4 These facts suggest that the manifestations of lead encephalopathy are a direct result of the presence of lead in the brain tissues. Currently, the chelating agent calcium disodium edetate (calcium References 1. Byers, R. K.: Lead Poisoning; Review of Literature and Report on 45 Cases , Pediatrics 23:585, 1959. 2. Kehoe, R. A.: Personal communication to the authors. 3. Chisolm, J. J., and Harrison, H. E.: Exposure of Children to Lead , Pediatrics 18:943, 1956. 4. Kehoe, R. A.: Harben Lectures, 1960: Metabolism of Lead in Man in Health and Disease; III. Present Hygienic Problems Relating to Absorption of Lead , J Roy Inst Public Health 24:177, 1961. 5. Chisolm, J. J., and Harrison, H. E.: Treatment of Acute Lead Encephalopathy in Children , Pediatrics 19:2, 1957. 6. Wolf, A. V., et al: Artificial Kidney Function: Kinetics of Hemodialysis , J Clin Invest 30:1062, 1951.Crossref
TI - Treatment of Lead Encephalopathy: The Combined Use of Edetate and Hemodialysis
JF - American Journal of Diseases of Children
DO - 10.1001/archpedi.1965.02090020324011
DA - 1965-04-01
UR - https://www.deepdyve.com/lp/american-medical-association/treatment-of-lead-encephalopathy-the-combined-use-of-edetate-and-PSYT0f6uhg
SP - 322
EP - 324
VL - 109
IS - 4
DP - DeepDyve
ER -