TY - JOUR
AU1 - Caldwell, Kenneth
AU2 - Lobell, Michael
AU3 - Coccia, Pater F.
AB - Abstract • A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. A marked mitogenic response of her cultured lymphocytes to Toxocara antigen but not to Ascaris antigen was found. A neutrophil chemotactic abnormality to Escherichia coli culture filtrates and zymosan-activated sera was also demonstrated, which partially corrected after she was treated with diethylcarbamazine citrate. (Am J Dis Child 134:845-847, 1980) References 1. Huntley CC, Costas MC, Lyerly A: Visceral larva migrans syndrome: Clinical characteristics and immunodiagnostic studies in 51 patients . Pediatrics 36:523-536, 1965. 2. Mok CH: Visceral larva migrans: A discussion based on review of the literature . Clin Pediatr 7:565-573, 1968.Crossref 3. Hogarth-Scott RS, Johansson SGO, Bennich H: Antibodies to Toxocara in the sera of visceral larva migrans patients: The significance of raised levels of IgE . Clin Exp Immunol 5:619-625, 1969. 4. Patterson R, Huntley CC, Roberts M, et al: Visceral larva migrans: Immunoglobulins, precipitating antibodies and detection of IgG and IgM antibodies against Toxocara antigen . Am J Trop Med Hyg 24:465-470, 1975. 5. Boyden SV: The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes . J Exp Med 115:453-466, 1962.Crossref 6. Hill HR, Quie PG: Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1:183-187, 1974.Crossref 7. Bowers TK, Craddock PR, Jacob HS: Acquired granulocyte abnormality during drug allergic reactions: Possible role of complement activation . Blood 49:3-8, 1977. 8. Craddock PR, Fehr J, Jacob HS: Complement-mediated granulocyte dysfunction in paroxysmal nocturnal hemoglobinuria . Blood 47:931-940, 1976. 9. Fontan G: Defective neutrophil chemotaxis and hyperimmunoglobulinemia E: A reversible defect? Acta Pediatr Scand 65:509-511, 1976.Crossref 10. Buckley RH, Wray BB, Belmaker EZ: Extreme hyperimmunoglobulinemia E and undue susceptibility to infection . Pediatrics 49:59-70, 1972.
TI - Mitogenic Response to Toxocara Antigen and Chemotactic Defect in Visceral Larva Migrans
JF - American Journal of Diseases of Children
DO - 10.1001/archpedi.1980.02130210029008
DA - 1980-09-01
UR - https://www.deepdyve.com/lp/american-medical-association/mitogenic-response-to-toxocara-antigen-and-chemotactic-defect-in-O4727z6qlY
SP - 845
EP - 847
VL - 134
IS - 9
DP - DeepDyve
ER -