TY - JOUR
AU1 - Sharma, Kartavya
AU2 - Johnson, Daniel
AU3 - Johnson, Brenda
AU4 - Frank, Steven
AU5 - Stevens, Robert
AB - Background: There is uncertainty regarding the effect of anemia and red blood cell transfusion on functional outcome following acute ischemic stroke. We studied the relationship of hemoglobin parameters and red cell transfusion with post stroke functional outcome after adjustment for neurological severity and medical comorbidities. Methods: Retrospective cohort study of 536 patients discharged with a diagnosis of ischemic stroke from a tertiary care hospital between January 2012 and April 2015. Hemoglobin level at hospital admission, lowest recorded value during hospitalization (nadir), delta hemoglobin (admission minus nadir), red cell transfusion during hospitalization were noted. Charlson Comorbidity Index (CCI) was computed as a summary measure of medical comorbidities. A multivariable logistic regression model was used to determine risk-adjusted odds of unfavorable outcome, defined as a modified Rankin Score of > 2. Results: Anemia was present on hospital admission in 31% of patients. Forty five percent of patients had unfavorable outcome. In the univariable analysis increasing age, admission National Institutes of Health Stroke Scale (NIHSS), CCI, nadir hemoglobin, delta hemoglobin and blood transfusion were associated with unfavorable outcome. In the multivariable model, only increasing age, CCI and NIHSS remained associated with unfavorable outcome. No quadratic association was found on repeating the model 
TI - Hemoglobin concentration does not impact 3-month outcome following acute ischemic stroke
JF - BMC Neurology
DO - 10.1186/s12883-018-1082-8
DA - 2018-06-02
UR - https://www.deepdyve.com/lp/springer-journals/hemoglobin-concentration-does-not-impact-3-month-outcome-following-NblgOAqihX
SP - 1
EP - 5
VL - 18
IS - 1
DP - DeepDyve
ER -