TY - JOUR
AU1 - Assunção, F.B.
AU2 - Fragoso, D.C.
AU3 - Scoppetta, T.L.P. Donoso
AU4 - Maia, A.C. Martins
AB - LETTERS COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease e read with great interest the article by Toledano-Massiah Even though the authors have concluded that the etiology Wet al entitled, “Unusual Brain MRI Pattern in 2 Patients and physiopathology of these unusual brain lesions are still not with COVID-19 Acute Respiratory Distress Syndrome.” The clarified, these 2 additional patients reinforce the inflammatory authors reported 2 patients hospitalized in their intensive care mechanism hypothesis. Acute disseminated encephalomyelitis unit with confirmed coronavirus disease 2019 (COVID-19) in (ADEM) is a rare immune-mediated demyelinating disease that whom brain MR imaging had shown an unusual DWI pattern has been associated with vaccine and viral infections, including with nodular and ring-shaped lesions involving the periventricu- SARS-CoV-2 infection. lar and deep white matter. Based on the recent literature, the The causative neuropathogenic mechanism of SARS-CoV- authors discussed the probable mechanism of action for Severe 2 infection should be carefully analyzed. In particular, Acute Respiratory Syndrome coronavirus disease 2 (SARS-CoV- patient 2 was asymptomatic for about 30 days, and the RT- 2) neurologic invasion. PCR test was not performed. Nevertheless, we presumed that We treated 2 hospitalized patients who share some simi- the infection had acted as a trigger for 
TI - COVID-19-Associated Acute Disseminated Encephalomyelitis–Like Disease
JF - American Journal of Neuroradiology
DO - 10.3174/ajnr.A6967
DA - 2021-04-01
UR - https://www.deepdyve.com/lp/american-journal-of-neuroradiology/covid-19-associated-acute-disseminated-encephalomyelitis-like-disease-Lras2QDzvu
SP - E21
EP - E23
VL - 42
IS - 4
DP - DeepDyve
ER -