TY - JOUR
AU1 - Call, D. J.
AU2 - Brooke, L. T.
AU3 - Knuth, M. L.
AU4 - Poirier, S. H.
AU5 - Hoglund, M. D.
AB - A model based on partition coefficient was developed for predicting subchronic toxicities of selected chemicals to fish. Early life stage tests were conducted under flow‐through conditions using fathead minnows (Pimephales promelas) as test organisms. Embryos, larvae and juveniles were continuously exposed to chemicals for a total of 31 to 33 d. Test endpoints included egg hatchability, incidence of developmental abnormalities, survival and growth. The “chronic value” for each test was a point estimate of the maximum acceptable toxicant concentration (MATC), and was determined as the geometric mean of the highest test concentration producing no effect and the lowest concentration significantly (p ≤ 0.05) affecting one or more endpoints. Ten industrial organic compounds from four chemical classes (ketones, benzenes, ethers and alkyl halides) were used in model development. All chemicals were considered to induce narcosis in fish in acute toxicity tests. The relationship between estimated MATC n‐octanol/water partition coefficient (log P) was expressed by the equation
TI - Fish subchronic toxicity prediction model for industrial organic chemicals that produce narcosis
JF - Environmental Toxicology & Chemistry
DO - 10.1002/etc.5620040308
DA - 1985-06-01
UR - https://www.deepdyve.com/lp/wiley/fish-subchronic-toxicity-prediction-model-for-industrial-organic-KefsSBNAnw
SP - 335
EP - 341
VL - 4
IS - 3
DP - DeepDyve
ER -