TY - JOUR
AU1 - Orville, Allen
AB - A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained.
TI - Entering an era of dynamic structural biology…
JF - BMC Biology
DO - 10.1186/s12915-018-0533-4
DA - 2018-05-31
UR - https://www.deepdyve.com/lp/springer-journals/entering-an-era-of-dynamic-structural-biology-HHgoJNZ0RM
SP - 1
EP - 4
VL - 16
IS - 1
DP - DeepDyve