TY - JOUR
AU1 - Hwang, Sungmin
AU2 - Schmiegelt, Benjamin
AU3 - Ferretti, Luca
AU4 - Krug, Joachim
AB - Kauffman’s NK-model is a paradigmatic example of a class of stochastic models of genotypic fitness landscapes that aim to capture generic features of epistatic interactions in multilocus systems. Genotypes are represented as sequences of L binary loci. The fitness assigned to a genotype is a sum of contributions, each of which is a random function defined on a subset of
$$k \le L$$
k
≤
L
loci. These subsets or neighborhoods determine the genetic interactions of the model. Whereas earlier work on the NK model suggested that most of its properties are robust with regard to the choice of neighborhoods, recent work has revealed an important and sometimes counter-intuitive influence of the interaction structure on the properties of NK fitness landscapes. Here we review these developments and present new results concerning the number of local fitness maxima and the statistics of selectively accessible (that is, fitness-monotonic) mutational pathways. In particular, we develop a unified framework for computing the exponential growth rate of the expected number of local fitness maxima as a function of L, and identify two different universality classes of interaction structures that display different asymptotics of this quantity for large k. Moreover, we show that the probability that the fitness landscape can be traversed along an accessible path decreases exponentially in L for a large class of interaction structures that we characterize as locally bounded. Finally, we discuss the impact of the NK interaction structures on the dynamics of evolution using adaptive walk models.
TI - Universality Classes of Interaction Structures for NK Fitness Landscapes
JF - Journal of Statistical Physics
DO - 10.1007/s10955-018-1979-z
DA - 2018-02-13
UR - https://www.deepdyve.com/lp/springer-journals/universality-classes-of-interaction-structures-for-nk-fitness-DAsU3H0sjQ
SP - 226
EP - 278
VL - 172
IS - 1
DP - DeepDyve