TY - JOUR
AU1 - Francoual, Jeanne
AU2 - Myara, Anne
AU3 - Benattar, Clarisse
AU4 - Ravaud, A.
AU5 - Paumier, Danièle
AU6 - Magny, J.-F.
AU7 - Messaoui, C.
AU8 - Trivin, F.
AB -  Introduction Neonatal hyperbilirubinaemia is currently observed during the neonatal period (25 -r 50% of all neonates), mostly due to low activity of the hepatic glucuronosyltransferase (EC 2.4.1.17) (1). Total and conjugated (or "direct") bilirubin determinations are necessary to identify the origin of the jaundice, to predict its evolution and to treat it. Visible light phototherapy is one of the effective treatments frequently given to these children, but it produces photochemical prod- ucts (2) that may interfere with the biochemical methods commonly used for bilirubin determination (3). The aim of this study is to compare the data of total and conjugated bilirubin measured in neonates, undergoing phototherapy or not, using two commonly employed methods: colorimetric diazo reaction on a Hitachi 717, dual wavelength reflectance on a Kodak Ektachem 700. High performance liquid chromatograpfay was then used for further investigation. ,_ , Eur. J. Clin. Chera. din. Biochem. / Vol. 31,1993 / No. 8 Materials and Methods Patient samples Serum samples were from 108 neonates during the first 15 days of life (mean age: 4.7 days; range: 1-14 days), submitted to the laboratory for a survey of the bilirubin course. The gestational ages of the infants ranged from 26 to 
TI - Investigation of Total and Conjugated Bilirubin Determination during the Neonatal Period
JF - Clinical Chemistry and Laboratory Medicine
DO - 10.1515/cclm.1993.31.8.499
DA - 1993-01-01
UR - https://www.deepdyve.com/lp/de-gruyter/investigation-of-total-and-conjugated-bilirubin-determination-during-78iEHFnY6h
SP - 499
EP - 502
VL - 31
IS - 8
DP - DeepDyve