TY - JOUR AU1 - Herttrich, Theresa AU2 - Daxer, Johann AU3 - Hiemisch, Andreas AU4 - Kluge, Jens AU5 - Merkenschlager, Andreas AU6 - Kratzsch, Jürgen AU7 - Scheuermann, Kathrin AU8 - Jenni, Oskar G. AU9 - Körner, Antje AU1 - Kiess, Wieland AU1 - Quante, Mirja AB - AbstractBackgroundAccumulating evidence suggests a relationship between sleep alterations and overweight/obesity in children. Our aim was to investigate the association of sleep measures other than obstructive sleep apnea or sleep duration with overweight/obesity and metabolic function in children.MethodsWe conducted a prospective cohort study in school- aged children (aged 5 to 8 years, prepubertal, and 12 to 15 years, pubertal) with overweight/obesity and normal-weight children. All children underwent a standardized in-laboratory polysomnography followed by a fasting blood assessment for glucose and metabolic testing. Subjective sleep measures were investigated by a 7-day sleep diary and questionnaire. We analyzed prepubertal and pubertal groups separately using logistic regression and partial correlation analyses.ResultsA total of 151 participants were analyzed. Overweight/obese children had significantly higher odds for arousal index (prepubertal children: 1.28, Confidence interval (CI): 1.06, 1.67; pubertal children: 1.65, CI: 1.19, 2.29) than normal-weight children, independent of age and gender. In prepubertal children, arousal-index was positively associated with C-peptide (r=0.30, p=0.01), whereas Minimum O2 saturation was negatively associated with triglycerides (r=−0.34, p=0.005), adjusting for age and sex. However, associations were attenuated by further adjustment for body mass index standard deviation scores (BMI-SDS). In pubertal children, higher level of apnea-hypopnea-index and pCO2 predicted increased lipoprotein (a) levels (r=0.35, p=0.03 and r=0.40, p=0.01, respectively), independent of age, sex, and BMI-SDS. A negative association was found between pCO2 and high-density lipoprotein (HDL)-cholesterol (r=−0.40, p=0.01).ConclusionsOverall, we report that sleep quality as measured by arousal index may be compromised by overweight and obesity in children and warrants attention in future intervention programs. TI - Association of sleep characteristics with adiposity markers in children JF - Journal of Pediatric Endocrinology and Metabolism DO - 10.1515/jpem-2019-0517 DA - 2020-07-28 UR - https://www.deepdyve.com/lp/de-gruyter/association-of-sleep-characteristics-with-adiposity-markers-in-300hCFYupU SP - 845 EP - 852 VL - 33 IS - 7 DP - DeepDyve ER -