TY - JOUR
AU1 - Paulissen, Leo J.
AU2 - Shechmeister, I. L.
AB - THE EFFECT OF SUBLETHAL WHOLE-BODY X RADIATION ON ACTIVE IMMUNITY LEO J. PAULISSEN* AND I. L. SHECHMEISTERt From the Department of Microbiology, School of Medicine, and Department of Bacteriology, School of Dentistry, Washington University, St. Louis 10, Missouri The effect of radiation on the response has been the subject of several recent to active immunization has been investi­ reports. It was found that exposure to gated primarily by comparing antibody radiation did not affect either the rate levels in normal and irradiated ani­ of destruction of passively administered I 6 8 mals. - When an antigen was adminis­ antibodies or, in the case of the ap­ tered early enough (3 days) prior to plicable neutralizing antibodies, their even lethal doses of radiation, no de­ protective action against the toxins tectable interference in antibody pro­ of Clostridium septicum and Clostridium 4 IO duction was observed (however, see tetani. Actively induced immunity 5 6 against Cl. tetani toxin was also found Kohn , Taliaferro et al and Stevens et aF). Administration of an antigen to be protective in irradiated animals provided the proper time relationship shortly after irradiation (5 hours), led to suppression of the antibody response. between antigen administration and 
TI - The Effect of Sublethal Whole-Body X Radiation on Active Immunity
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/103.2.188
DA - 1958-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-effect-of-sublethal-whole-body-x-radiation-on-active-immunity-zmoFK6y9vY
SP - 188
EP - 195
VL - 103
IS - 2
DP - DeepDyve
ER -