TY - JOUR
AU - Ledger, William J.
AB - Peripheral blood mononuclear cells (PBMC) from 9 of 18 women with laparoscopy-verified salpingitis proliferated in response to recombinant Chlamydia trachomatis 57-kDa heat shock protein (hsp). In contrast, PBMC from 0 of 10 women with cervicitis, 1 of 5 women with recurrent abortions, and 3 (7.1%) of 42 healthy reproductive-age women were responsive to hsp (P < .001). After passage of the hsp through an endotoxin-removing column, PBMC from 6 of 14 additional women with salpingitis were responsive to hsp, while those from 10 controls, including the 3 previously positive women, were negative. PBMC from all patients responsive to the chlamydial hsp were unresponsive to Mycobacterium bovis 65-kDa hsp, PBMC from 6 ofthe 15 women with a positive hsp-induced lymphocyte response were unresponsive to C. trachomatis elementary bodies. Induction of a cell-mediated immune response to the chlamydial 57-kDa hsp is a common feature of an upper genital tract infection but does not appear to be limited to women with apparent chlamydial infections.
TI - Cell-Mediated Immune Response to the Recombinant 57-kDa Heat-Shock Protein of Chlamydia trachomatis in Women with Salpingitis
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/167.6.1379
DA - 1993-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/cell-mediated-immune-response-to-the-recombinant-57-kda-heat-shock-zi9h1zoLPb
SP - 1379
EP - 1383
VL - 167
IS - 6
DP - DeepDyve
ER -