TY - JOUR
AU - Ruscetti, Francis W.
AB - The ability of baicalin (7-g1ucuronic acid, 5,6-dihydroxyflavone), a flavonoid compound purified from the Chinese medicinal herb, Scutellaria baicalensis georgi, to inhibit human T cell leukemia virus type 1(HTLV-I) was examined. Baicalin produced concentration-dependent inhibition of HTLV-I replication in productively infected T and B cells. Moreover, baicalin treatment selectively reduced the detectable levels of HTLV-I p19 gag protein in infected cells by > 70% at concentrations that produced insignificant effects on total cellular protein and DNA synthesis with no loss in cell viability. Resistance to HTLV-I infection and virus-mediated transformation was noted in uninfected peripheral blood lymphocytes pretreated with baicalin before cocultivation with lethally irradiated chronically infected cells. Baicalin inhibited reverse transcriptase activity in HTLV-I—infected cells as well as the activity of purified reverse transcriptase from Moloney murine leukemia virus and Rous-associated virus type 2. These results suggest that baicalin may be a potential therapeutic agent against HTLV-I-associated T cell diseases.
TI - Inhibition of Human T Cell Leukemia Virus by the Plant Flavonoid Baicalin (7-Glucuronic Acid, 5,6-Dihydroxyflavone)
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/165.3.433
DA - 1992-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/inhibition-of-human-t-cell-leukemia-virus-by-the-plant-flavonoid-zcUn0JKXop
SP - 433
EP - 437
VL - 165
IS - 3
DP - DeepDyve
ER -