TY - JOUR
AU - Clark, James E.
AB - Abstract Erythrokinetic studies on two anephric and asplenic patients are described. The patients were nephrectomized in preparation for renal homotransplantation and maintained on hemodialysis for six and eight months. Results of these studies indicate that despite absence of kidneys and spleen, and intrinsic base line erythropoietic activity remains, with a relatively constant and persistent reticulocyte production and radioiron turnover. Autonomy of this erythropoietic activity was apparent by lack of responsiveness to induced anemia and polycythemia. In the second patient a reticulocytosis and increased iron turnover occurred five months postnephrectomy. This was accompanied by significant plasma titers of erythropoietin-like substance. A renin-like enzyme was also found in the plasma of both patients. These observations suggest the existence of an autonomous base line erythropoietic activity of bone marrow and a possible functional relationship between inappropriate secretion of extrarenal "erythropoietin" and extrarenal "renin." References 1. Erslev, A.J.: The Role of Erythropoietin in the Control of Red Cell Production , Medicine 43:661-665 ( (Nov) ) 1964.Crossref 2. Nathan, D.G., et al: Erythropoiesis in Anephric Man , J Clin Invest 43:2158-2165 ( (Nov) ) 1964.Crossref 3. Bothwell, T.H., et al: Erythrokinetics: IV. Plasma Iron Turnover as a Measure of Erythropoiesis , Blood 12:409-427 ( (May) ) 1957. 4. Rosse, W.F., and Waldman, T.A.: " Bio-assays of Erythropoietin: A Method Using Transfused Polycythemic Mice ," in Sunderman, F.W., and Sunderman, F.W., Jr. (eds.): Hemoglobin: Its Precursors and Metabolites , Philadelphia: J. B. Lippincott Co., 1964, pp 269-272. 5. Brown, J.J., et al: The Estimation of Renin in Human Plasma , Biochem J 93:594-600 ( (Oct) ) 1964. 6. Naets, J.P.: The Role of the Kidney in Erythropoiesis , J Clin Invest 39:102-110 ( (Jan) ) 1960.Crossref 7. Reissmann, K.R., et al: Erythropoietic Response to Anemia or Erythropoietin Injection in Uremic Rats With and Without Functioning Renal Tissue , Blood 16:1411-1423 ( (Oct) ) 1960. 8. Erslev, A.J.: Erythropoietic Function in Uremic Rabbits , Arch Intern Med 101:407-417 ( (Feb) ) 1958.Crossref 9. Rosse, W.F., and Waldman, T.A.: The Role of the Kidney in the Erythropoietic Response to Hypoxia in Parabiotic Rats , Blood 19:75-81 ( (Jan) ) 1962. 10. Mirand, E.A., and Prentice, T.C.: Presence of Plasma Erythropoietin in Hypoxic Rats With or Without Kidney (s) and/or Spleen , Proc Soc Exp Biol Med 96:49-51 ( (Oct) ) 1957.Crossref 11. Erslev, A.J.: Erythropoietic Function in Uremic Rabbits: II. Effects of Nephrectomy on Red Cell Production and Iron Metabolism , Acta Haemat 23:226-235, 1960.Crossref 12. Erslev, A.J.: The Anemia of Renal Failure , Kidney 1:1-5 ( (March) ) 1968. 13. Capelli, J.P., et al: Characterization and Source of a Renin-Like Enzyme in Anephric Humans , J Clin Endocr 28:221-230 ( (Feb) ) 1968.Crossref 14. Hirashima, K., and Takaku, F.: Experimental Studies on Erythropoietin: II. The Relationship Between Juxtaglomerular Cells and Erythropoietin , Blood 20:1-8 ( (July) ) 1962. 15. Mitus, W.J.; Toyama, K.; and Braner, M.J.: Erythrocytosis, Juxtaglomerular Apparatus (JGA) and Erythropoietin in the Course of Experimental Unilateral Hydronephrosis in Rabbits , Ann NY Acad Sci 149:107-113 ( (March) ) 1968.Crossref 16. Contrera, J.F.; Gordon, A.S.; and Weintraub, A.H.: Extraction of an Erythropoietin-Producing Factor From a Particulate Fraction of Rat Kidney , Blood 28:330-343 ( (Sept) ) 1966. 17. Zanjani, E.D., et al: The Renal Erythropoietic Factors (R.E.F.): III. Enzymatic Role in Erythropoietin Production , Proc Soc Exp Biol Med 125: 505-508 ( (June) ) 1967.Crossref 18. Kuratowska, Z.; Lewartowski, B.; and Lipinski, B.: Chemical and Biologic Properties of an Erythropoietin-Generating Substance Obtained From Perfusates of Isolated Anoxic Kidneys , J Lab Clin Med 64:226-237 ( (Aug) ) 1964. 19. Fisher, J.A.; Samuels, A.J.; and Langston, J.W.: Effects of Angiotensin and Renal Artery Constriction on Erythropoietin Production , J Pharmacol Exp Ther 157:618-625 ( (Sept) ) 1967. 20. Hennessy, T.G.; Stern, W.E.; and Herrick, S.E.: Cerebellar Hemangioblastoma: Erythropoietic Activity by Radiation Assay , J Nucl Med 8:601-606 ( (Aug) ) 1967. 21. Santer, M.A.; Waldman, T.A.; and Fallon, H.J.: Erythrocytosis and Hyperlipemia as Manifestations of Hepatic Carcinoma , Arch Intern Med 120:735-739 ( (Dec) ) 1967.Crossref
TI - Rate of Red Cell Production in Two Nephrectomized Patients
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1968.00300080038008
DA - 1968-09-01
UR - https://www.deepdyve.com/lp/american-medical-association/rate-of-red-cell-production-in-two-nephrectomized-patients-zRMsFM6L0S
SP - 230
EP - 235
VL - 122
IS - 3
DP - DeepDyve
ER -