TY - JOUR
AB - Editor Norman K. Hollenberg, MD, PhD Harvard Medical School and Brigham and Women’s Hospital, Department of Radiology, 15 Francis Street, Boston, MA 02115, USA. Voyaki SM, Staessen JA, Thijs L, et al., for the Systolic Hypertension in Europe (Syst-Eur) Trial Inves- tigators: Follow-up of renal function in treated and untreated older patients with isolated sys- tolic hypertension. J Hypertens 2001, 9:511–519. Abstract: In the outcome trials that provided information on renal function in older hypertensive patients, diuretics and beta blockers were mostly used as first-time drugs. The long-term renal effects of calcium channel blockers remain unclear. Our objective was to compare the changes in renal function in 2258 treated and 2148 untreated patients with isolated systolic hypertension, of whom 455 had diabetes mellitus and 390 had proteinuria. We performed a post-hoc analysis of the dou- ble-blind, placebo-controlled Systolic Hypertension in Europe (Syst-Eur) Trial. Active treatment was initiated with nitrendipine (10–40 mg/d) with the possible addition of enalapril (5–20 mg/d), hydrochlorothiazide (12.5–25 mg/d), or both, titrated or combined to reduce the sitting systolic blood pressure by at least 20 mm Hg, to less than 150 mm Hg. The main outcome measures were serum creatinine concentration and creatinine clearance calculated by 
TI - Literature alert
JF - Current Hypertension Reports
DO - 10.1007/s11906-002-0045-y
DA - 2002-05-21
UR - https://www.deepdyve.com/lp/springer-journals/literature-alert-zQhFnfsi0s
SP - 5
EP - 7
VL - 4
IS - 1
DP - DeepDyve
ER -