TY - JOUR
AU1 - Chen, A.
AU2 - Chapman,  C.
AB - 221 39 39 4 4 A. C. N. Chen C. R. Chapman Department of Anesthesiology University of Washington RN-10 98195 Seattle WA USA Department of Psychology University of Washington 98195 Seattle WA USA Department of Psychiatry and Behavioral Sciences University of Washington 98195 Seattle WA USA Summary The mechanism of aspirin analgesia is still unclear, but it is generally assumed that aspirin exerts its analgesic effect mainly on peripheral nociceptors. In this study, we demonstrate possible brain effects of 975 mg aspirin in man. When brain electrical potentials evoked by painful electrical tooth shocks were examined, aspirin was observed to significantly reduce the amplitude of the late waveform components, but it did not affect the earlier components. Since our earlier findings suggest that early waveform components reflect the energy transmission and the late components manifest the brain activities in an individual's perception of painful information, we postulate that aspirin may act centrally in pain processing.
TI - Aspirin analgesia evaluated by event-related potentials in man: Possible central action in brain
JF - Experimental Brain Research
DO - 10.1007/BF00239300
DA - 1980-07-01
UR - https://www.deepdyve.com/lp/springer-journals/aspirin-analgesia-evaluated-by-event-related-potentials-in-man-zOKBdp73s3
SP - 359
EP - 364
VL - 39
IS - 4
DP - DeepDyve
ER -