TY - JOUR
AU - Amer, Adel
AB - The transformation of 2‐chloro‐3‐(5‐(acetoxymethyl)‐1‐phenylpyrazol‐3‐yl)quinoxaline 3 to 1‐aryl‐4‐(5‐(hydroxymethyl‐1‐phenylpyrazol‐3‐yl)(1,2,4)triazolo(4,3‐a)quinoxalines 4a‐c has been achieved upon treatment with aroylhydrazines in boiling butanol. Compounds 4a‐c were smoothly acetylated by acetic anhydride to give their acetyl derivatives 5a‐c in good yield. 4‐(5‐(Acetoxymethyl)‐1‐phenylpyrazol‐3‐yl)‐1‐methyl(1,2,4)triazolo(4,3‐a)quinoxaline was prepared by ring closure of 2‐hydrazino‐3‐(5‐(hydroxymethyl)‐1‐phenylpyrazol‐3‐yl)quinoxaline 6 by the action of acetic anhydride. The reaction of 6 with acetylacetone afforded 3‐(5‐(hydroxymethyl)‐1‐phenylpyrazol‐3‐yl)‐2‐(3,5‐dimethylpyrazol‐1‐yl)quinoxaline 8. In addition, the reaction of 3 with sodium azide in boiling N, N‐dimethylformamide yielded the fused tetrazolo(1,5‐a)quinoxaline 9.
TI - Synthesis of 4(pyrazol‐3‐yl)(1,2,4)triazolo(4,3‐ a )quinoxalines and tetrazolo analog
JF - Journal of Heterocyclic Chemistry
DO - 10.1002/jhet.5570310250
DA - 1994-03-01
UR - https://www.deepdyve.com/lp/wiley/synthesis-of-4-pyrazol-3-yl-1-2-4-triazolo-4-3-a-quinoxalines-and-zNrA0dv6UY
SP - 549
EP - 552
VL - 31
IS - 2
DP - DeepDyve
ER -