TY - JOUR
AU - Guinchard, C.
AB - Using a rapid chemometric methodology to determine the separation factor, α, at different temperatures, Gibbs Helmholtz parameters (Δ (ΔH), Δ (ΔS), Δ (ΔG)) of two adjacent benodiazepines on a chromatogram were obtained from ln α versus T−1 plots. A temperature dependent reversal of the elution order was studied and the mobile phase composition and column temperature were optimized to obtain the best separation. A flow rate of 0.80 ml min−1 with 52.6% methanol in the methanol-water mixture and a column temperature of 48°C gave the most efficient separation of ten benzodiazepines.
TI - Thermodynamic behavior of mixed benzodiazepines by a new liquid chromatographic method
JF - Chromatographia
DO - 10.1007/BF02272170
DA - 2005-11-15
UR - https://www.deepdyve.com/lp/springer-journals/thermodynamic-behavior-of-mixed-benzodiazepines-by-a-new-liquid-zLkqJMxL6G
SP - 193
EP - 196
VL - 40
IS - 4
DP - DeepDyve
ER -