TY - JOUR
AU - Boyse, Edward A.
AB - Abstract This is a review and discussion of studies leading to the first use of human umbilical cord blood, material usually discarded, for the provision of stem/progenitor cells for clinical hematopoietic reconstitution [1,2]. This prospect arose as a result of extensive studies of the harvesting and cryopreservation of cord blood and of its numerical content of progenitor cells demonstrable in vitro. A male patient with Fanconi anemia (FA) was conditioned with a modified regimen of cyclophosphamide and irradiation that accommodates the abnormally high sensitivity to these agents that is characteristic of FA. Cryopreserved cord blood had been retrieved at birth from a female sibling known from prenatal testing to be unaffected by FA and to be human leukocyte antigen (HLA)-compatible with the prospective sibling recipient. After conditioning and therapeutic infusion of thawed cord blood, successful hematopoietic reconstitution was indicated by the general health of the patient, who had previously required supportive transfusions, by satisfactory hematological criteria and by counts of hematopoietic progenitor cells of various types in the bone marrow. Complete engraftment of the myeloid system with donor cells was evident from cytogenetics, ABO typing, study of DNA polymorphisms, and normal cellular resistance to cytotoxic agents that reveal the fragility of FA cells; the blood contained a residuum of host lymphocytes exhibiting chromosomal damage, but the trend has been towards eliminating these damaged cells. This implies that cord blood from a single individual should provide sufficient reconstituting cells for effective hematopoietic repopulation of an autologous or an HLA-compatible allogeneic recipient. Umbilical cord blood, Hematopoietic stem/progenitor cells Hematopoietic reconstituting cells References 1 Broxmeyer HE , Douglas GW, Hangoc G, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells . Proc Natl Acad Sci USA 1989 ; 86 : 3828 – 3832 . Google Scholar Crossref Search ADS PubMed WorldCat 2 Gluckman E , Broxmeyer HE, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of blood from an HLA-identical sibling . N Engl J Med 1989 ; 321 : 1174 – 1178 . Google Scholar Crossref Search ADS PubMed WorldCat 3 Broxmeyer HE . Biomolecule-cell interactions and regulation of myelopoiesis . Int J Cell Cloning 1986 ; 4 : 378 – 405 . Google Scholar Crossref Search ADS PubMed WorldCat 4 Broxmeyer HE , Williams DE. The production of myeloid blood cells and their regulation during health and disease . CRC Crit Rev Oncol/Hematol 1988 ; 8 ;173–226. 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TI - Human umbilical cord blood: A clinically useful source of transplantable hematopoietic stem/progenitor cells
JF - Stem Cells
DO - 10.1002/stem.5530080708
DA - 1990-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/human-umbilical-cord-blood-a-clinically-useful-source-of-zCvRYP94P6
SP - 76
EP - 91
VL - 8
IS - S1
DP - DeepDyve
ER -