TY - JOUR
AU - ,
AB - Polymerase chain reaction (PCR) was used to detect human immunodeficiency virus (HIV)1 DNA in peripheral blood mononuclear cells to assess in hemophilic men whether any were HIV-seropositive but uninfected or seronegative but infected and in seronegative sex partners of seropositive hemophilic men whether any were infected. Of 40 seropositive men, 38 (95%) were PCR-positive; one was PCR-indeterminate and one PCR-negative. None of 41 seronegative men who used only donor-screened, virus-inactivated coagulation factor products were PCR-positive. However, two of six who received noninactivated products were PCR-positive; one had low T-helper cell counts and died of unrelated causes and the other had seroconverted 11 mo later. PCR with a second primer pair also detected HIV-1 DNA in these two men. None of 25 seronegative female sex partners of seropositive men, including six men with AIDS and seven with AIDS-related symptoms, were PCR-positive. These data suggest that most seropositive hemophilic men are HIV-infected; whether some are infected with defective virus remains to be resolved as does the infection status of seropositive PCR-negative men. Identification of two seronegative PCRpositive men supports the possibility that HIV-1 DNAcan be detected before seroconversion.
TI - Prevalence of Human Immunodeficiency Virus Type 1 DNA in Hemophilic Men and Their Sex Partners
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/160.5.789
DA - 1989-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/prevalence-of-human-immunodeficiency-virus-type-1-dna-in-hemophilic-z62KBZ0PGq
SP - 789
EP - 794
VL - 160
IS - 5
DP - DeepDyve
ER -