TY - JOUR
AU1 - MATTIE, D., R.
AU2 - BATES, G., D.
AU3 - JEPSON, G., W.
AU4 - FISHER, J., W.
AU5 - MCDOUGAL, J., N.
AB - Abstract The partition coefficient (PC) of a chemical in skin is an indicator of the capacity for a chemical in the skin and may reflect the rate at which a chemical penetrates the skin and enters into systemic circulation. In this study we present a simple method to measure the skin:air PC for volatile organic chemicals. Important considerations in the development of this method for a skin:air PC were the effect of size and shape of the skin sample, initial chemical concentration, and time to equilibrium in the skin. Clipped, whole-thickness skin was obtained from the dorsal surface of 8- to 16-week-old male F-344 rats. After removal of the hypodermis, skin was cut into strips and placed on the side of a glass vial. An organic chemical vapor was introduced into a sealed sample vial (initial concentration before equilibration was 203 ppm) and a corresponding reference vial, which were equilibrated at 32°C. Headspace concentrations at equilibrium were used to determine a skin:air PC value. After developing the technique using dibromomethane, a skin:air PC value was determined for perchloroethylene, trichloroethylene, ben zene, hexane, toluene, m-xylene, styrene, methyl chloroform, methylene chloride, carbon tetrachloride, halothane, and isoflurane. The skin:air PC values correlated with previously deter mined vapor permeability constants but correlated poorly with octanol/water PC values. This method provides a screening technique for predicting skin penetration of volatile chemicals. This content is only available as a PDF. © 1994 by the Society of Toxicology
TI - Determination of Skin:Air Partition Coefficients for Volatile Chemicals: Experimental Method and Applications
JF - Toxicological Sciences
DO - 10.1093/toxsci/22.1.51
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/determination-of-skin-air-partition-coefficients-for-volatile-yssg0x5iBO
SP - 51
EP - 57
VL - 22
IS - 1
DP - DeepDyve
ER -