TY - JOUR
AU - Jantchou, Prévost
AB - Background Digestive endoscopies must be performed within a safe and comfortable environment. We have previously shown that the quality of intravenous sedation is influenced by preoperative stress. Aim Our primary objective was to compare the effects of oral lorazepam and placebo on the salivary cortisol response of children undergoing a digestive endoscopy. Secondary objectives were the assessment of procedural pain and comfort as well as the occurrence of adverse events. Methods Participants were randomized and received either lorazepam, placebo, or no premedication. Saliva was col- lected upon arrival at the hospital and 1 h following randomization. The sedation protocol included midazolam and fen- tanyl ± ketamine. Procedural pain was evaluated with the Nurse Assessed Patient Comfort Score (NAPCOMS). Patients completed a postoperative questionnaire. The primary outcome was defined as the proportion of children having a cortisol decrease ≥ 15 nmol/L. Results 101 participants (54 females) were included. The rate of children having a cortisol decrease ≥ 15 nmol/L was 27.3%, 35.3%, and 19.4% for lorazepam, placebo, and no premedication, respectively (p = 0.356). The median (IQR) NAPCOMS pain score was 3.0 (0–6) for lorazepam, 4.4 (0–6) for placebo, and 3.4 (3–4) for no premedication (p = 0.428). With loraz- epam, 75.9% of 
TI - Oral Lorazepam is not Superior to Placebo for Lowering Stress in Children Before Digestive Endoscopy: A Double-Blind, Randomized, Controlled Trial
JF - Pediatric Drugs
DO - 10.1007/s40272-019-00351-9
DA - 2019-08-16
UR - https://www.deepdyve.com/lp/springer-journals/oral-lorazepam-is-not-superior-to-placebo-for-lowering-stress-in-yhWwDM1Sa6
SP - 379
EP - 387
VL - 21
IS - 5
DP - DeepDyve
ER -